|
|
|
|
Direct interaction between two viral proteins,the nonstructural protein 2CATPase and the capsid protein VP3,is required for enterovirus morphogenesis
|
|
|
|
|
|
|
|
نویسنده
|
liu y. ,wang c. ,mueller s. ,paul a.v. ,wimmer e. ,jiang p.
|
|
منبع
|
plos pathogens - 2010 - دوره : 6 - شماره : 8 - صفحه:75 -76
|
|
چکیده
|
In spite of decades-long studies,the mechanism of morphogenesis of plus-stranded rna viruses belonging to the genus enterovirus of picornaviridae,including poliovirus (pv),is not understood. numerous attempts to identify an rna encapsidation signal have failed. genetic studies,however,have implicated a role of the non-structural protein 2catpase in the formation of poliovirus particles. here we report a novel mechanism in which protein-protein interaction is sufficient to explain the specificity in pv encapsidation. making use of a novel reporter virus
|
|
کلیدواژه
|
we show that a quasi-infectious chimera consisting of the capsid precursor of C-cluster coxsackie virus 20 (C-CAV20) and the nonstructural proteins of the closely related PV translated and replicated its genome with wild type kinetics
|
|
آدرس
|
department of molecular genetics and microbiology,school of medicine,stony brook university,stony brook,ny, United States, department of molecular genetics and microbiology,school of medicine,stony brook university,stony brook,ny, United States, department of molecular genetics and microbiology,school of medicine,stony brook university,stony brook,ny, United States, department of molecular genetics and microbiology,school of medicine,stony brook university,stony brook,ny, United States, department of molecular genetics and microbiology,school of medicine,stony brook university,stony brook,ny, United States, department of molecular genetics and microbiology,school of medicine,stony brook university,stony brook,ny, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|