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The transcription factor rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis
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نویسنده
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heimel k. ,scherer m. ,vranes m. ,wahl r. ,pothiratana c. ,schuler d. ,vincon v. ,finkernagel f. ,flor-parra i. ,kämper j.
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منبع
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plos pathogens - 2010 - دوره : 6 - شماره : 8 - صفحه:17 -18
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چکیده
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In the phytopathogenic basidiomycete ustilago maydis,sexual and pathogenic development are tightly connected and controlled by the heterodimeric be/bw transcription factor complex encoded by the b-mating type locus. the formation of the active be/bw heterodimer leads to the formation of filaments,induces a g2 cell cycle arrest,and triggers pathogenicity. here,we identify a set of 345 be/bw responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination,morphogenesis and pathogenicity. 90% of the genes that show altered expression upon be/bw-activation require the zinc finger transcription factor rbf1,one of the few factors directly regulated by the be/bw heterodimer. rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development. © 2010 heimel et al.
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آدرس
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karlsruhe institute of technology,institute for applied biosciences,department of genetics,karlsruhe,germany,mpi for terrestrial microbiology,department for organismic interactions,marburg, Germany, mpi for terrestrial microbiology,department for organismic interactions,marburg,germany,qiagen gmbh,hilden, Germany, karlsruhe institute of technology,institute for applied biosciences,department of genetics,karlsruhe,germany,mpi for terrestrial microbiology,department for organismic interactions,marburg, Germany, karlsruhe institute of technology,institute for applied biosciences,department of genetics,karlsruhe,germany,mpi for terrestrial microbiology,department for organismic interactions,marburg, Germany, mpi for terrestrial microbiology,department for organismic interactions,marburg,germany,kasetsart university,department of microbiology,bangkok, Thailand, karlsruhe institute of technology,institute for applied biosciences,department of genetics,karlsruhe, Germany, mpi for terrestrial microbiology,department for organismic interactions,marburg, Germany, institute for molecular biology and tumor research,marburg, Germany, centro andaluz de biologi ́a del desarrollo,universidad pablo de olavide-consejo superior de investigaciones científicas,sevilla, Spain, karlsruhe institute of technology,institute for applied biosciences,department of genetics,karlsruhe,germany,mpi for terrestrial microbiology,department for organismic interactions,marburg, Germany
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Authors
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