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Phylodynamics and Human-mediated dispersal of a zoonotic virus
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نویسنده
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talbi c. ,lemey p. ,suchard m.a. ,abdelatif e. ,elharrak m. ,jalal n. ,faouzi a. ,echevarría j.e. ,morón s.v. ,rambaut a. ,campiz n. ,tatem a.j. ,holmes e.c. ,bourhy h.
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منبع
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plos pathogens - 2010 - دوره : 6 - شماره : 10
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چکیده
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Understanding the role of humans in the dispersal of predominately animal pathogens is essential for their control. we used newly developed bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (rabv) in north africa. each of the countries studied exhibited largely disconnected spatial dynamics with major geopolitical boundaries acting as barriers to gene flow. road distances proved to be better predictors of the movement of dog rabv than accessibility or raw geographical distance,with occasional long distance and rapid spread within each of these countries. using simulations that bridge phylodynamics and spatial epidemiology,we demonstrate that the contemporary viral distribution extends beyond that expected for rabv transmission in african dog populations. these results are strongly supportive of human-mediated dispersal,and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing,predicting,and potentially controlling the spatial spread of pathogens. © 2010 talbi et al.
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آدرس
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institut pasteur,unit lyssavirus dynamics and host adaptation,who collaborating centre for reference and research on rabies,paris, France, rega institute,katholieke universiteit leuven,leuven, Belgium, departments of biomathematics and human genetics,david geffen school of medicine,and department of biostatistics,school of public health,university of california,los angeles,ca, United States, institut pasteur d'algérie,laboratoire de la rage,recherche et diagnostic,alger, Algeria, biopharma laboratoire,rabbat, Morocco, institut pasteur du maroc,laboratoire de virologie médicale,casablanca, Morocco, institut pasteur du maroc,laboratoire de virologie médicale,casablanca, Morocco, instituto de salud carlos iii,servicio de microbiología diagnóstica,madrid, Spain, instituto de salud carlos iii,servicio de microbiología diagnóstica,madrid, Spain, institute of evolutionary biology,university of edinburgh,ashworth laboratories,edinburgh,united kingdom,fogarty international center,national institutes of health,bethesda,md, United States, department of geography,university of florida,gainesville,fl, United States, department of geography,university of florida,gainesville,fl,united states,emerging pathogens institute,university of florida,gainesville,fl, United States, fogarty international center,national institutes of health,bethesda,md,united states,center for infectious disease dynamics,department of biology,the pennsylvania state university,university park,pa, United States, institut pasteur,unit lyssavirus dynamics and host adaptation,who collaborating centre for reference and research on rabies,paris, France
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Authors
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