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Genital tract sequestration of SIV following acute infection
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نویسنده
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whitney j.b. ,hraber p.t. ,luedemann c. ,giorgi e.e. ,daniels m.g. ,bhattacharya t. ,rao s.s. ,mascola j.r. ,nabel g.j. ,korber b.t. ,letvin n.l.
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منبع
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plos pathogens - 2011 - دوره : 7 - شماره : 2
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چکیده
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We characterized the evolution of simian immunodeficiency virus (siv) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. at the time of peak virus replication,siv sequences were intermixed between the blood and semen supporting a scenario of high-level virus spillover into the male genital tract. however,at the time of virus set point,compartmentalization was apparent in 4 of 7 evaluated monkeys,likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. these findings suggest that siv replication in the male genital tract evolves to compartmentalization after peak viremia resolves. © 2011 whitney et al.
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آدرس
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division of viral pathogenesis,department of medicine,beth israel deaconess medical center,boston,ma,united states,harvard medical school,boston,ma, United States, los alamos national laboratory,los alamos,nm, United States, division of viral pathogenesis,department of medicine,beth israel deaconess medical center,boston,ma, United States, los alamos national laboratory,los alamos,nm, United States, los alamos national laboratory,los alamos,nm, United States, los alamos national laboratory,los alamos,nm, United States, vaccine research center,national institutes of allergy and infectious diseases,bethesda,md, United States, vaccine research center,national institutes of allergy and infectious diseases,bethesda,md, United States, vaccine research center,national institutes of allergy and infectious diseases,bethesda,md, United States, los alamos national laboratory,los alamos,nm, United States, division of viral pathogenesis,department of medicine,beth israel deaconess medical center,boston,ma,united states,harvard medical school,boston,ma,united states,vaccine research center,national institutes of allergy and infectious diseases,bethesda,md, United States
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Authors
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