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Environmental constraints guide migration of malaria parasites during transmission
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نویسنده
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hellmann j.k. ,münter s. ,kudryashev m. ,schulz s. ,heiss k. ,müller a.-k. ,matuschewski k. ,spatz j.p. ,schwarz u.s. ,frischknecht f.
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منبع
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plos pathogens - 2011 - دوره : 7 - شماره : 6
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چکیده
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Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue. during transmission of malaria,parasite motility in the skin is important for plasmodium sporozoites to reach the blood circulation. here we show that sporozoite migration varies in different skin environments the parasite encounters at the arbitrary sites of the mosquito bite. in order to systematically examine how sporozoite migration depends on the structure of the environment,we studied it in micro-fabricated obstacle arrays. the trajectories observed in vivo and in vitro closely resemble each otion and correlates with persistence length and dispersal. however,this correlation breaks down in mutant sporozoites that show adhesion impairment due to the lack of trap-like protein (tlp) on their surfaces. this may explain their delay in infecting the host. the flexibility of sporozoite adaption to different environments and a favorable speed for optimal dispersal ensures efficient host switching during malaria transmission. © 2011 hellmann et al.
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آدرس
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parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg, Germany, parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg, Germany, parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg, Germany, max planck institute for metals research,department of new materials and biosystems,university of heidelberg,department of biophysical chemistry,stuttgart, Germany, parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg, Germany, parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg, Germany, parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg,germany,max planck institute for infection biology,department of parasitology,berlin, Germany, max planck institute for metals research,department of new materials and biosystems,university of heidelberg,department of biophysical chemistry,stuttgart, Germany, institute for theoretical physics and bioquant,university of heidelberg,heidelberg, Germany, parasitology,department of infectious diseases,university of heidelberg medical school,heidelberg, Germany
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Authors
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