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CD39/adenosine pathway is involved in AIDS progression
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نویسنده
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nikolova m. ,carriere m. ,jenabian m.-a. ,limou s. ,younas m. ,kök a. ,huë s. ,seddiki n. ,hulin a. ,delaneau o. ,schuitemaker h. ,herbeck j.t. ,mullins j.i. ,muhtarova m. ,bensussan a. ,zagury j.-f. ,lelievre j.-d. ,lévy y.
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منبع
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plos pathogens - 2011 - دوره : 7 - شماره : 7
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چکیده
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Hiv-1 infection is characterized by a chronic activation of the immune system and suppressed function of t lymphocytes. regulatory cd4+ cd25 high foxp3+cd127 low t cells (treg) play a key role in both conditions. here,we show that hiv-1 positive patients have a significant increase of treg-associated expression of cd39/entpd1,an ectoenzyme which in concert with cd73 generates adenosine. we show in vitro that the cd39/adenosine axis is involved in treg suppression in hiv infection. treg inhibitory effects are relieved by cd39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine a2a receptor on patients' t cells. notably,the expansion of the treg cd39+ correlates with the level of immune activation and lower cd4+ counts in hiv-1 infected patients. finally,in a genetic association study performed in three different cohorts,we identified a cd39 gene polymorphism that was associated with down-modulated cd39 expression and a slower progression to aids. © 2011 nikolova et al.
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آدرس
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inserm,unite u955,creteil,france,national center of infectious and parasitic diseases,sofia, Bulgaria, inserm,unite u955,creteil, France, inserm,unite u955,creteil, France, inserm,unite u955,creteil,france,chaire de bioinformatique,conservatoire national des arts et métiers,paris, France, inserm,unite u955,creteil, France, inserm,unite u955,creteil, France, inserm,unite u955,creteil, France, inserm,unite u955,creteil, France, ap-hp,groupe henri-mondor albert-chenevier,laboratory of pharmacology and toxicology,creteil, France, chaire de bioinformatique,conservatoire national des arts et métiers,paris, France, department of experimental immunology,sanquin research,landsteiner laboratory,center for infectious diseases and immunity amsterdam (cinima) academic medical center,university of amsterdam,amsterdam, Netherlands, university of washington,school of medicine,department of microbiology,seattle,wa, United States, university of washington,school of medicine,department of microbiology,seattle,wa, United States, national center of infectious and parasitic diseases,sofia, Bulgaria, inserm umr 976 and universite denis-diderot-paris 7,hopital saint-louis,paris, France, inserm,unite u955,creteil,france,chaire de bioinformatique,conservatoire national des arts et métiers,paris, France, inserm,unite u955,creteil,france,université paris est créteil,faculté de médecine,creteil,france,ap-hp,groupe henri-mondor albert-chenevier,immunologie clinique,creteil, France, inserm,unite u955,creteil,france,université paris est créteil,faculté de médecine,creteil,france,ap-hp,groupe henri-mondor albert-chenevier,immunologie clinique,creteil, France
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Authors
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