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KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection
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نویسنده
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seich al basatena n.-k. ,macnamara a. ,vine a.m. ,thio c.l. ,astemborski j. ,usuku k. ,osame m. ,kirk g.d. ,donfield s.m. ,goedert j.j. ,bangham c.r.m. ,carrington m. ,khakoo s.i. ,asquith b.
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منبع
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plos pathogens - 2011 - دوره : 7 - شماره : 10
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چکیده
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Killer cell immunoglobulin-like receptors (kirs) influence both innate and adaptive immunity. but while the role of kirs in nk-mediated innate immunity is well-documented,the impact of kirs on the t cell response in human disease is not known. here we test the hypothesis that an individual's kir genotype affects the efficiency of their hla class i-mediated antiviral immune response and the outcome of viral infection. we show that,in two unrelated viral infections,hepatitis c virus and human t lymphotropic virus type 1,possession of the kir2dl2 gene enhanced both protective and detrimental hla class i-restricted anti-viral immunity. these results reveal a novel role for inhibitory kirs. we conclude that inhibitory kirs,in synergy with t cells,are a major determinant of the outcome of persistent viral infection.
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آدرس
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imperial college,london, United Kingdom, imperial college,london, United Kingdom, imperial college,london, United Kingdom, johns hopkins university,baltimore,md, United States, johns hopkins university,baltimore,md, United States, kumamoto university,kumamoto, Japan, kagoshima university,kumamoto, Japan, johns hopkins university,baltimore,md, United States, rho,chapel hill,nc, United States, national cancer institute,rockville,md, United States, imperial college,london, United Kingdom, cancer and inflammation program,laboratory of experimental immunology,saic-frederick,inc.,nci-frederick,frederick,md,united states,ragon institute of mgh,mit and harvard,boston,ma, United States, imperial college,london, United Kingdom, imperial college,london, United Kingdom
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Authors
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