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A phenome-based functional analysis of transcription factors in the cereal head blight fungus,fusarium graminearum
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نویسنده
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son h. ,seo y.-s. ,min k. ,park a.r. ,lee j. ,jin j.-m. ,lin y. ,cao p. ,hong s.-y. ,kim e.-k. ,lee s.-h. ,cho a. ,lee s. ,kim m.-g. ,kim y. ,kim j.-e. ,kim j.-c. ,choi g.j. ,yun s.-h. ,lim j.y. ,kim m. ,lee y.-h. ,choi y.-d. ,lee y.-w.
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منبع
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plos pathogens - 2011 - دوره : 7 - شماره : 10
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چکیده
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Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. the fungus produces mycotoxins that are harmful to animal and human. in this study,a systematic analysis of 17 phenotypes of the mutants in 657 fusarium graminearum genes encoding putative transcription factors (tfs) resulted in a database of over 11,000 phenotypes (phenome). this database provides comprehensive insights into how this cereal pathogen of global significance regulates traits important for growth,development,stress response,pathogenesis,and toxin production and how transcriptional regulations of these traits are interconnected. in-depth analysis of tfs involved in sexual development revealed that mutations causing defects in perithecia development frequently affect multiple other phenotypes,and the tfs associated with sexual development tend to be highly conserved in the fungal kingdom. besides providing many new insights into understanding the function of f. graminearum tfs,this mutant library and phenome will be a valuable resource for characterizing the gene expression network in this fungus and serve as a reference for studying how different fungi have evolved to control various cellular processes at the transcriptional level. © 2011 son et al.
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آدرس
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dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, department of applied biology,dong-a university,busan, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, china tobacco gene research center,zhengzhou tobacco research institute,zhengzhou,henan, China, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, chemical biotechnology center,korea research institute of chemical technology,daejon, South Korea, chemical biotechnology center,korea research institute of chemical technology,daejon, South Korea, department of medical biotechnology,soonchunhyang university,asan, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea, dept of agricultural biotechnology and centers for fungal pathogenesis and agricultural biomaterials,seoul national university,seoul, South Korea
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Authors
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