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Critical roles for light and its receptors in generating T cell-mediated immunity during Leishmania Donovani infection
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نویسنده
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stanley a.c. ,de labastida rivera f. ,haque a. ,sheel m. ,zhou y. ,amante f.h. ,bunn p.t. ,randall l.m. ,pfeffer k. ,scheu s. ,hickey m.j. ,saunders b.m. ,ware c. ,hill g.r. ,tamada k. ,kaye p.m. ,engwerda c.r.
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منبع
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plos pathogens - 2011 - دوره : 7 - شماره : 10
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چکیده
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Light (tnfsf14) is a member of the tnf superfamily involved in inflammation and defence against infection. light signals via two cell-bound receptors; herpes virus entry mediator (hvem) and lymphotoxin-beta receptor (ltβr). we found that light is critical for control of hepatic parasite growth in mice with visceral leishmaniasis (vl) caused by infection with the protozoan parasite leishmania donovani. light-hvem signalling is essential for early dendritic cell il-12/il-23p40 production,and the generation of ifnγ- and tnf-producing t cells that control hepatic infection. however,we also discovered that light-ltβr interactions suppress anti-parasitic immunity in the liver in the first 7 days of infection by mechanisms that restrict both cd4 + t cell function and tnf-dependent microbicidal mechanisms. thus,we have identified distinct roles for light in infection,and show that manipulation of interactions between light and its receptors may be used for therapeutic advantage. © 2011 stanley et al.
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آدرس
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queensland institute of medical research,the australian centre for vaccine development,herston,qld,australia,institute for molecular biology,university of queensland,st lucia,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld,australia,department of pathobiology,school of veterinary sciences,university of pennsylvania,philadelphia,pa, United States, institute of medical microbiology and hospital hygiene,university of duesseldorf,duesseldorf, Germany, institute of medical microbiology and hospital hygiene,university of duesseldorf,duesseldorf, Germany, centre for inflammatory diseases,monash university,department of medicine,monash medical centre,clayton,vic, Australia, centenary institute,newtown,nsw, Australia, infectious and inflammatory diseases centre,sanford burnham medical research institute,la jolla,ca, Australia, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia, marlene and stewart greenebaum cancer center,university of maryland,baltimore,md, United States, hull york medical school,department of biology,york university,york, United Kingdom, queensland institute of medical research,the australian centre for vaccine development,herston,qld, Australia
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Authors
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