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A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa
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نویسنده
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grard g. ,fair j.n. ,lee d. ,slikas e. ,steffen i. ,muyembe j.-j. ,sittler t. ,veeraraghavan n. ,ruby j.g. ,wang c. ,makuwa m. ,mulembakani p. ,tesh r.b. ,mazet j. ,rimoin a.w. ,taylor t. ,schneider b.s. ,simmons g. ,delwart e. ,wolfe n.d. ,chiu c.y. ,leroy e.m.
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منبع
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plos pathogens - 2012 - دوره : 8 - شماره : 9
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چکیده
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Deep sequencing was used to discover a novel rhabdovirus (bas-congo virus,or basv) associated with a 2009 outbreak of 3 human cases of acute hemorrhagic fever in mangala village,democratic republic of congo (drc),africa. the cases,presenting over a 3-week period,were characterized by abrupt disease onset,high fever,mucosal hemorrhage,and,in two patients,death within 3 days. basv was detected in an acute serum sample from the lone survivor at a concentration of 1.09×106 rna copies/ml,and 98.2% of the genome was subsequently de novo assembled from ~140 million sequence reads. phylogenetic analysis revealed that basv is highly divergent and shares less than 34% amino acid identity with any other rhabdovirus. high convalescent neutralizing antibody titers of >1:1000 were detected in the survivor and an asymptomatic nurse directly caring for him,both of whom were health care workers,suggesting the potential for human-to-human transmission of basv. the natural animal reservoir host or arthropod vector and precise mode of transmission for the virus remain unclear. basv is an emerging human pathogen associated with acute hemorrhagic fever in africa. © 2012 grard et al.
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آدرس
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viral emergent diseases unit,centre international de recherches médicales de franceville,franceville,gabon,mivegec,umr (ird 224 - cnrs 5290 - um1 - um2),institut de recherche pour le développement,montpellier, France, global viral forecasting,incorporated,san francisco,ca, United States, department of laboratory medicine,university of california,san francisco,ca,united states,ucsf-abbott viral diagnostics and discovery center,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, institut national de recherche biomédicale,kinshasa, Democratic Republic Congo, department of laboratory medicine,university of california,san francisco,ca,united states,ucsf-abbott viral diagnostics and discovery center,san francisco,ca, United States, department of laboratory medicine,university of california,san francisco,ca,united states,ucsf-abbott viral diagnostics and discovery center,san francisco,ca, United States, howard hughes medical institute,chevy chase,md,united states,department of biochemistry,university of california,san francisco,ca, United States, department of biochemistry,stanford university,stanford,ca, United States, institut national de recherche biomédicale,kinshasa, Democratic Republic Congo, institut national de recherche biomédicale,kinshasa, Democratic Republic Congo, department of pathology,university of texas medical branch,galveston,tx, United States, department of epidemiology,university of california at davis,davis,ca, United States, department of epidemiology,university of california at los angeles,los angeles,ca, United States, global viral forecasting,incorporated,san francisco,ca, United States, global viral forecasting,incorporated,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, global viral forecasting,incorporated,san francisco,ca, United States, department of laboratory medicine,university of california,san francisco,ca,united states,ucsf-abbott viral diagnostics and discovery center,san francisco,ca,united states,department of medicine,division of infectious diseases,university of california,san francisco,san francisco,ca, United States, viral emergent diseases unit,centre international de recherches médicales de franceville,franceville,gabon,mivegec,umr (ird 224 - cnrs 5290 - um1 - um2),institut de recherche pour le développement,montpellier, France
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Authors
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