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Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice
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نویسنده
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cho j.s. ,guo y. ,ramos r.i. ,hebroni f. ,plaisier s.b. ,xuan c. ,granick j.l. ,matsushima h. ,takashima a. ,iwakura y. ,cheung a.l. ,cheng g. ,lee d.j. ,simon s.i. ,miller l.s.
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منبع
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plos pathogens - 2012 - دوره : 8 - شماره : 11
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چکیده
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Neutrophil abscess formation is critical in innate immunity against many pathogens. here,the mechanism of neutrophil abscess formation was investigated using a mouse model of staphylococcus aureus cutaneous infection. gene expression analysis and in vivo multispectral noninvasive imaging during the s. aureus infection revealed a strong functional and temporal association between neutrophil recruitment and il-1β/il-1r activation. unexpectedly,neutrophils but not monocytes/macrophages or other mhcii-expressing antigen presenting cells were the predominant source of il-1β at the site of infection. furthermore,neutrophil-derived il-1β was essential for host defense since adoptive transfer of il-1β-expressing neutrophils was sufficient to restore the impaired neutrophil abscess formation in s. aureus-infected il-1β-deficient mice. s. aureus-induced il-1β production by neutrophils required tlr2,nod2,fpr1 and the asc/nlrp3 inflammasome in an α-toxin-dependent mechanism. taken together,il-1β and neutrophil abscess formation during an infection are functionally,temporally and spatially linked as a consequence of direct il-1β production by neutrophils. © 2012 cho et al.
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آدرس
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department of medicine,division of dermatology,david geffen school of medicine at university of california los angeles (ucla),los angeles,ca, United States, department of medicine,division of dermatology,david geffen school of medicine at university of california los angeles (ucla),los angeles,ca, United States, department of medicine,division of dermatology,david geffen school of medicine at university of california los angeles (ucla),los angeles,ca, United States, department of medicine,division of dermatology,david geffen school of medicine at university of california los angeles (ucla),los angeles,ca, United States, department of translational immunology,dirks/dougherty laboratory for cancer research,john wayne cancer institute,santa monica,ca, United States, department of translational immunology,dirks/dougherty laboratory for cancer research,john wayne cancer institute,santa monica,ca, United States, department of biomedical engineering,university of california davis,davis,ca, United States, department of medical microbiology and immunology,university of toledo college of medicine,toledo,oh, United States, department of medical microbiology and immunology,university of toledo college of medicine,toledo,oh, United States, center for experimental medicine and systems biology,institute of medical science,university of tokyo,minato-ku,tokyo,japan,core research for evolutional science and technology (crest),japan science and technology agency,saitama, Japan, department of microbiology and immunology,dartmouth medical school,hanover,nh, United States, department of microbiology,immunology,and molecular genetics,david geffen school of medicine at university of california los angeles (ucla),los angeles,ca, United States, department of translational immunology,dirks/dougherty laboratory for cancer research,john wayne cancer institute,santa monica,ca, United States, department of biomedical engineering,university of california davis,davis,ca, United States, department of dermatology,johns hopkins university school of medicine,baltimore,md, United States
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Authors
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