|
|
|
|
Antigenic Subversion: A Novel Mechanism of Host Immune Evasion by Ebola Virus
|
|
|
|
|
|
|
|
نویسنده
|
mohan g.s. ,li w. ,ye l. ,compans r.w. ,yang c.
|
|
منبع
|
plos pathogens - 2012 - دوره : 8 - شماره : 12
|
|
چکیده
|
In addition to its surface glycoprotein (gp1,2),ebola virus (ebov) directs the production of large quantities of a truncated glycoprotein isoform (sgp) that is secreted into the extracellular space. the generation of secreted antigens has been studied in several viruses and suggested as a mechanism of host immune evasion through absorption of antibodies and interference with antibody-mediated clearance. however such a role has not been conclusively determined for the ebola virus sgp. in this study,we immunized mice with dna constructs expressing gp1,2 and/or sgp,and demonstrate that sgp can efficiently compete for anti-gp12 antibodies,but only from mice that have been immunized by sgp. we term this phenomenon antigenic subversion
|
|
کلیدواژه
|
and propose a model whereby sGP redirects the host antibody response to focus on epitopes which it shares with membrane-bound GP1
|
|
آدرس
|
department of microbiology and immunology,emory university,atlanta,ga, United States, department of microbiology and immunology,emory university,atlanta,ga,united states,department of parasitology,zhongshan school of medicine,sun yat-sen university,guangzhou, China, department of microbiology and immunology,emory university,atlanta,ga, United States, department of microbiology and immunology,emory university,atlanta,ga, United States, department of microbiology and immunology,emory university,atlanta,ga, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|