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Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco,Peru: A Case Series
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نویسنده
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cabada m.m. ,lopez m. ,cruz m. ,delgado j.r. ,hill v. ,white a.c.
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منبع
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plos neglected tropical diseases - 2016 - دوره : 10 - شماره : 1
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چکیده
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Triclabendazole is reported to be highly effective in treatment of human fascioliasis. we present 7 of 19 selected cases of human fascioliasis referred to our center in the cusco region of peru that failed to respond to triclabendazole. these were mostly symptomatic adults of both sexes that continued passing fasciola eggs in the stool despite multiple treatments with 2 doses of triclabendazole at 10 mg/kg per dose. we documented the presence of eggs by rapid sedimentation and kato katz tests after each treatment course. we found that repeated triclabendazole courses were not effective against fascioliasis in this group of people. these findings suggest that resistance to triclabendazole may be an emerging problem in the andes. © 2016 cabada et al.
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آدرس
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department of internal medicine,university of texas medical branch,galveston,tx,united states,sede cusco—instituto de medicina tropical alexander von humboldt,universidad peruana cayetano heredia,lima, Peru, sede cusco—instituto de medicina tropical alexander von humboldt,universidad peruana cayetano heredia,lima, Peru, hospital nivel iv adolfo guevara velasco essalud,cusco, Peru, sede cusco—instituto de medicina tropical alexander von humboldt,universidad peruana cayetano heredia,lima, Peru, sede cusco—instituto de medicina tropical alexander von humboldt,universidad peruana cayetano heredia,lima,peru,college of natural sciences,university of texas at austin,austin,tx, United States, jr.,department of internal medicine,university of texas medical branch,galveston,tx, United States
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Authors
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