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Rheopathologic Consequence of Plasmodium vivax Rosette Formation
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نویسنده
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zhang r. ,lee w.-c. ,lau y.-l. ,albrecht l. ,lopes s.c.p. ,costa f.t.m. ,suwanarusk r. ,nosten f. ,cooke b.m. ,rénia l. ,russell b.
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منبع
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plos neglected tropical diseases - 2016 - دوره : 10 - شماره : 8
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چکیده
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Malaria parasites dramatically alter the rheological properties of infected red blood cells. in the case of plasmodium vivax,the parasite rapidly decreases the shear elastic modulus of the invaded rbc,enabling it to avoid splenic clearance. this study highlights correlation between rosette formation and altered membrane deformability of p. vivax-infected erythrocytes,where the rosette-forming infected erythrocytes are significantly more rigid than their non-rosetting counterparts. the adhesion of normocytes to the pvirbc is strong (mean binding force of 440pn) resulting in stable rosette formation even under high physiological shear flow stress. rosetting may contribute to the sequestration of pvirbc schizonts in the host microvasculature or spleen. © 2016 zhang et al.
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آدرس
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department of microbiology and immunology,yong loo lin school of medicine,national university of singapore,national university health system, Singapore, singapore immunology network (sign),agency for science,technology and research (a*star), Singapore, department of parasitology,faculty of medicine,university of malaya,kuala lumpur, Malaysia, laboratory of tropical diseases,instituto de biologia,universidade estadual de campinas (unicamp),campinas-sp,brazil,instituto carlos chagas,fundação oswaldo cruz—fiocruz,curitiba,pr, Brazil, laboratory of tropical diseases,instituto de biologia,universidade estadual de campinas (unicamp),campinas-sp,brazil,instituto leônidas e marie deane,fiocruz,manaus,am, Brazil, laboratory of tropical diseases,instituto de biologia,universidade estadual de campinas (unicamp),campinas-sp, Brazil, singapore immunology network (sign),agency for science,technology and research (a*star), Singapore, shoklo malaria research unit,mahidol-oxford tropical medicine research unit,faculty of tropical medicine,mahidol university,maesot,thailand,centre for tropical medicine,nuffield department of medicine,university of oxford,oxford, United Kingdom, programs in infection and immunity and cardiovascular disease,monash biomedicine discovery institute and department of microbiology,monash universityvic, Australia, singapore immunology network (sign),agency for science,technology and research (a*star), Singapore, department of microbiology and immunology,yong loo lin school of medicine,national university of singapore,national university health system,singapore,department of microbiology and immunology,university of otago,dunedin, New Zealand
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Authors
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