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Bacillus cereus Biovar Anthracis Causing Anthrax in Sub-Saharan Africa—Chromosomal Monophyly and Broad Geographic Distribution
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نویسنده
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antonation k.s. ,grützmacher k. ,dupke s. ,mabon p. ,zimmermann f. ,lankester f. ,peller t. ,feistner a. ,todd a. ,herbinger i. ,de nys h.m. ,muyembe-tamfun j.-j. ,karhemere s. ,wittig r.m. ,couacy-hymann e. ,grunow r. ,calvignac-spencer s. ,corbett c.r. ,klee s.r. ,leendertz f.h.
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منبع
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plos neglected tropical diseases - 2016 - دوره : 10 - شماره : 9
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چکیده
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Through full genome analyses of four atypical bacillus cereus isolates,designated b. cereus biovar anthracis,we describe a distinct clade within the b. cereus group that presents with anthrax-like disease,carrying virulence plasmids similar to those of classic bacillus anthracis. we have isolated members of this clade from different mammals (wild chimpanzees,gorillas,an elephant and goats) in west and central africa (côte d’ivoire,cameroon,central african republic and democratic republic of congo). the isolates shared several phenotypic features of both b. anthracis and b. cereus,but differed amongst each other in motility and their resistance or sensitivity to penicillin. they all possessed the same mutation in the regulator gene plcr,different from the one found in b. anthracis,and in addition,carry genes which enable them to produce a second capsule composed of hyaluronic acid. our findings show the existence of a discrete clade of the b. cereus group capable of causing anthrax-like disease,found in areas of high biodiversity,which are possibly also the origin of the worldwide distributed b. anthracis. establishing the impact of these pathogenic bacteria on threatened wildlife species will require systematic investigation. furthermore,the consumption of wildlife found dead by the local population and presence in a domestic animal reveal potential sources of exposure to humans. © 2016 antonation et al.
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آدرس
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national microbiology laboratory,public health agency of canada,winnipeg,mb, Canada, project group epidemiology of highly pathogenic microorganisms,robert koch-institute,berlin,germany,world wide fund for nature - germany,berlin, Germany, center for biological threats and special pathogens,robert koch-institute,berlin, Germany, national microbiology laboratory,public health agency of canada,winnipeg,mb, Canada, project group epidemiology of highly pathogenic microorganisms,robert koch-institute,berlin,germany,center for biological threats and special pathogens,robert koch-institute,berlin, Germany, paul g. allen school for global animal health,washington state university,pullman,wa, United States, world wide fund for nature - car,bangui, Central African Republic, world wide fund for nature - car,bangui, Central African Republic, world wide fund for nature - car,bangui, Central African Republic, world wide fund for nature - germany,berlin, Germany, project group epidemiology of highly pathogenic microorganisms,robert koch-institute,berlin, Germany, institut national de recherche biomédicale,kinshasa, Congo, institut national de recherche biomédicale,kinshasa, Congo, max-planck-institute for evolutionary anthropology,department of primatology,leipzig,germany,taï chimpanzee project,centre suisse de recherches scientifiques,abidjan, Cote d'Ivoire, laboratoire national d’appui au développement agricole,laboratoire central vétérinaire de bingerville, Cote d'Ivoire, center for biological threats and special pathogens,robert koch-institute,berlin, Germany, project group epidemiology of highly pathogenic microorganisms,robert koch-institute,berlin, Germany, national microbiology laboratory,public health agency of canada,winnipeg,mb,canada,department of medical microbiology,university of manitobamb, Canada, center for biological threats and special pathogens,robert koch-institute,berlin, Germany, project group epidemiology of highly pathogenic microorganisms,robert koch-institute,berlin, Germany
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Authors
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