|
|
|
|
Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays
|
|
|
|
|
|
|
|
نویسنده
|
uplekar s. ,rao p.n. ,ramanathapuram l. ,awasthi v. ,verma k. ,sutton p. ,ali s.z. ,patel a. ,sri lakshmi priya g. ,ravishankaran s. ,desai n. ,tandel n. ,choubey s. ,barla p. ,kanagaraj d. ,eapen a. ,pradhan k. ,singh r. ,jain a. ,felgner p.l. ,davies d.h. ,carlton j.m. ,das j.
|
|
منبع
|
plos neglected tropical diseases - 2017 - دوره : 11 - شماره : 1
|
|
چکیده
|
Understanding naturally acquired immune responses to plasmodium in india is key to improving malaria surveillance and diagnostic tools. here we describe serological profiling of immune responses at three sites in india by probing protein microarrays consisting of 515 plasmodium vivax and 500 plasmodium falciparum proteins with 353 plasma samples. a total of 236 malaria-positive (symptomatic and asymptomatic) plasma samples and 117 malaria-negative samples were collected at three field sites in raurkela,nadiad,and chennai. indian samples showed significant seroreactivity to 265 p. vivax and 373 p. falciparum antigens,but overall seroreactivity to p. vivax antigens was lower compared to p. falciparum antigens. we identified the most immunogenic antigens of both plasmodium species that were recognized at all three sites in india,as well as p. falciparum antigens that were associated with asymptomatic malaria. this is the first genome-scale analysis of serological responses to the two major species of malaria parasite in india. the range of immune responses characterized in different endemic settings argues for targeted surveillance approaches tailored to the diverse epidemiology of malaria across the world. © 2017 uplekar et al.
|
|
|
|
|
آدرس
|
center for genomics and systems biology,department of biology,new york university,new york,ny, United States, center for genomics and systems biology,department of biology,new york university,new york,ny, United States, center for genomics and systems biology,department of biology,new york university,new york,ny,united states,memorial sloan kettering cancer center,new york,ny, United States, national institute of malaria researchn council of medical research,sector 8,dwarka,new delhi, India, national institute of malaria researchn council of medical research,sector 8,dwarka,new delhi, India, center for genomics and systems biology,department of biology,new york university,new york,ny,united states,acsel health,500 5th ave,suite 2760,new york,ny, United States, national institute of malaria research field unit,sector 1 health center,raurkela,odisha, India, national institute of malaria research field unit,civil hospital,nadiad,gujarat, India, national institute of malaria research field unitn council of medical research,national institute of epidemiology campus,ayapakkam,chennai,tamil nadu, India, national institute of malaria research field unitn council of medical research,national institute of epidemiology campus,ayapakkam,chennai,tamil nadu, India, national institute of malaria research field unit,civil hospital,nadiad,gujarat, India, national institute of malaria research field unit,civil hospital,nadiad,gujarat, India, national institute of malaria research field unit,sector 1 health center,raurkela,odisha, India, national institute of malaria research field unit,sector 1 health center,raurkela,odisha, India, national institute of malaria research field unitn council of medical research,national institute of epidemiology campus,ayapakkam,chennai,tamil nadu, India, national institute of malaria research field unitn council of medical research,national institute of epidemiology campus,ayapakkam,chennai,tamil nadu, India, national institute of malaria research field unit,sector 1 health center,raurkela,odisha, India, national institute of malaria research field unit,civil hospital,nadiad,gujarat, India, department of medicine,division of infectious diseases,university of california irvine,irvine,ca, United States, department of medicine,division of infectious diseases,university of california irvine,irvine,ca, United States, department of medicine,division of infectious diseases,university of california irvine,irvine,ca, United States, center for genomics and systems biology,department of biology,new york university,new york,ny, United States, national institute of malaria researchn council of medical research,sector 8,dwarka,new delhi, India
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|