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Disinfection of Ebola Virus in Sterilized Municipal Wastewater
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نویسنده
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bibby k. ,fischer r.j. ,casson l.w. ,de carvalho n.a. ,haas c.n. ,munster v.j.
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منبع
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plos neglected tropical diseases - 2017 - دوره : 11 - شماره : 2
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چکیده
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Concerns have been raised regarding handling of ebola virus contaminated wastewater,as well as the adequacy of proposed disinfection approaches. in the current study,we investigate the inactivation of ebola virus in sterilized domestic wastewater utilizing sodium hypochlorite addition and ph adjustment. no viral inactivation was observed in the one-hour tests without sodium hypochlorite addition or ph adjustment. no virus was recovered after 20 seconds (i.e. 4.2 log10unit inactivation to detection limit) following the addition of 5 and 10 mg l-1sodium hypochlorite,which resulted in immediate free chlorine residuals of 0.52 and 1.11 mg l-1,respectively. the addition of 1 mg l-1sodium hypochlorite resulted in an immediate free chlorine residual of 0.16 mg l-1,which inactivated 3.5 log10units of ebola virus in 20 seconds. further inactivation was not evident due to the rapid consumption of the chlorine residual. elevating the ph to 11.2 was found to significantly increase viral decay over ambient conditions. these results indicate the high susceptibility of the enveloped ebola virus to disinfection in the presence of free chlorine in municipal wastewater; however,we caution that extension to more complex matrices (e.g. bodily fluids) will require additional verification. © 2017 public library of science. all rights reserved.
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آدرس
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department of civil and environmental engineering,university of pittsburgh,pittsburgh,pa,united states,department of computational and systems biology,university of pittsburgh,pittsburgh,pa, United States, laboratory of virology,division of intramural research,national institute of allergy and infectious diseases,national institutes of health,hamilton,mt, United States, department of civil and environmental engineering,university of pittsburgh,pittsburgh,pa, United States, department of civil and environmental engineering,university of pittsburgh,pittsburgh,pa, United States, department of civil,architectural & environmental engineering,drexel university,philadelphia,pa, United States, laboratory of virology,division of intramural research,national institute of allergy and infectious diseases,national institutes of health,hamilton,mt, United States
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Authors
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