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The clinical burden of human cystic echinococcosis in Palestine,2010-2015
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نویسنده
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al-jawabreh a. ,ereqat s. ,dumaidi k. ,nasereddin a. ,al-jawabreh h. ,azmi k. ,al-laham n. ,nairat m. ,casulli a. ,maqboul h. ,abdeen z.
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منبع
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plos neglected tropical diseases - 2017 - دوره : 11 - شماره : 7
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چکیده
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Background: cystic echinococcosis (ce) is classified by the who as a neglected disease inflicting economic losses on the health systems of many countries worldwide. the aim of this case-series study was to investigate the burden of human ce in palestine during the period between 2010 and 2015. methodology/principal findings: records of surgically confirmed ce patients from 13 public and private hospitals in the west bank and gaza strip were reviewed. patients’ cysts were collected from surgical wards and formalin-fixed paraffin-embedded (ffpe) blocks were collected from histopathology departments. molecular identification of ce species /genotypes was conducted by targeting a repeat dna sequence (egg1 hae iii) within echinococcus nuclear genome and a fragment within the mitochondrial cytochrome c oxidase subunit 1,(co1). confirmation of ce species/genotypes was carried out using sequencing followed by blast analysis and the construction of maximum likelihood consensus dendrogram. ce cases were map-spotted and statistically significant foci identified by spatial analysis. a total of 353 ce patients were identified in 108 localities from the west bank and gaza strip. the average surgical incidence in the west bank was 2.1 per 100,000. spot-mapping and purely spatial analysis showed 13 out of 16 palestinian districts had cases of ce,of which 9 were in the west bank and 4 in gaza strip. al-khalil and bethlehem were statistically significant foci of ce in palestine with a six-year average incidence of 4.2 and 3.7 per 100,000,respectively. conclusions/significance: to the best of our knowledge,this is the first confirmation of human ce causative agent in palestine. this study revealed that e. granulosus sensu stricto (s.s.) was the predominating species responsible for ce in humans with 11 samples identified as g1 genotype and 2 as g3 genotype. this study emphasizes the need for a stringent surveillance system and risk assessment studies in the rural areas of high incidence as a prerequisite for control measures. © 2017 al-jawabreh et al.
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آدرس
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department of medical laboratory sciences,faculty of allied health sciences,arab american university,jenin,palestine,al-quds public health society,jerusalem, Palestine, al-quds public health society,jerusalem,palestine,biochemistry and molecular biology department,faculty of medicine,al-quds university,abu deis,east jerusalem,palestine,al-quds nutrition and health research institute,al-quds university,east jerusalem, Palestine, department of medical laboratory sciences,faculty of allied health sciences,arab american university,jenin, Palestine, al-quds public health society,jerusalem,palestine,al-quds nutrition and health research institute,al-quds university,east jerusalem, Palestine, al-quds public health society,jerusalem, Palestine, al-quds public health society,jerusalem,palestine,biochemistry and molecular biology department,faculty of medicine,al-quds university,abu deis,east jerusalem,palestine,al-quds nutrition and health research institute,al-quds university,east jerusalem, Palestine, department of laboratory medicine,faculty of applied medical sciences,alazhar university–gaza,gaza strip, Palestine, palestine medical complex,ministry of health,ramallah, Palestine, world health organization collaborating centre for the epidemiology,detection and control of cystic and alveolar echinococcosis (in humans and animals),istituto superiore di sanità,rome,italy,european union reference laboratory for the parasites,istituto superiore di sanità,rome, Italy, faculty of medicine and health sciences,an-najah national university,nablus, Palestine, al-quds public health society,jerusalem,palestine,al-quds nutrition and health research institute,al-quds university,east jerusalem, Palestine
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Authors
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