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Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites
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نویسنده
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tajebe f. ,getahun m. ,adem e. ,hailu a. ,lemma m. ,fikre h. ,raynes j. ,tamiru a. ,mulugeta z. ,diro e. ,toulza f. ,shkedy z. ,ayele t. ,modolell m. ,munder m. ,müller i. ,takele y. ,kropf p.
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منبع
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plos neglected tropical diseases - 2017 - دوره : 11 - شماره : 7
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چکیده
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Visceral leishmaniasis (vl) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. visceral leishmaniasis is characterized by the presence of leishmania parasites in the spleen,liver and bone marrow,hepatosplenomegaly,pancytopenia,prolonged fever,systemic inflammation and low body mass index (bmi). the factors impacting on the severity of vl are poorly characterized. here we performed a cross-sectional study to assess whether co-infection of vl patients with intestinal parasites influences disease severity,assessed with clinical and haematological data,inflammation,cytokine profiles and bmi. data from vl patients was similar to vl patients co-infected with intestinal parasites,suggesting that co-infection of vl patients with intestinal parasites does not alter disease severity. © 2017 tajebe et al.
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آدرس
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department of immunology and molecular biology,university of gondar,gondar, Ethiopia, department of immunology and molecular biology,university of gondar,gondar,ethiopia,ethiopian public health institute,addis ababa, Ethiopia, leishmaniasis research and treatment centre,university of gondar,gondar, Ethiopia, department of microbiology,immunology and parasitology,addis ababa university,addis ababa, Ethiopia, department of internal medicine,university of gondar,gondar, Ethiopia, leishmaniasis research and treatment centre,university of gondar,gondar, Ethiopia, department of immunology and infection,london school of hygiene and tropical medicine,london, United Kingdom, leishmaniasis research and treatment centre,university of gondar,gondar, Ethiopia, leishmaniasis research and treatment centre,university of gondar,gondar, Ethiopia, leishmaniasis research and treatment centre,university of gondar,gondar,ethiopia,department of internal medicine,university of gondar,gondar, Ethiopia, department of haematological medicine,faculty of life sciences,king’s college,london, United Kingdom, department of mathematics and statistics,university of hasselt,hasselt, Belgium, department of mathematics and statistics,university of hasselt,hasselt, Belgium, department of cellular immunology,max-planck-institute for immunobiology and epigenetics,freiburg, Germany, third department of medicine (hematology,oncology and pneumology),university medical center mainz,mainz, Germany, department of medicine,imperial college london,london, United Kingdom, leishmaniasis research and treatment centre,university of gondar,gondar,ethiopia,department of medicine,imperial college london,london, United Kingdom, department of medicine,imperial college london,london, United Kingdom
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Authors
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