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Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area,Brazil
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نویسنده
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styczynski a.r. ,malta j.m.a.s. ,krow-lucal e.r. ,percio j. ,nóbrega m.e. ,vargas a. ,lanzieri t.m. ,leite p.l. ,staples j.e. ,fischer m.x. ,powers a.m. ,chang g.-j.j. ,burns p.l. ,borland e.m. ,ledermann j.p. ,mossel e.c. ,schonberger l.b. ,belay e.b. ,salinas j.l. ,badaro r.d. ,sejvar j.j. ,coelho g.e.
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منبع
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plos neglected tropical diseases - 2017 - دوره : 11 - شماره : 8
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چکیده
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In mid-2015,salvador,brazil,reported an outbreak of guillain-barré syndrome (gbs),coinciding with the introduction and spread of zika virus (zikv). we found that gbs incidence during april–july 2015 among those ≥12 years of age was 5.6 cases/100,000 population/year and increased markedly with increasing age to 14.7 among those ≥60 years of age. we conducted interviews with 41 case-patients and 85 neighborhood controls and found no differences in demographics or exposures prior to gbs-symptom onset. a higher proportion of case-patients (83%) compared to controls (21%) reported an antecedent illness (or 18.1,ci 6.9–47.5),most commonly characterized by rash,headache,fever,and myalgias,within a median of 8 days prior to gbs onset. our investigation confirmed an outbreak of gbs,particularly in older adults,that was strongly associated with zika-like illness and geo-temporally associated with zikv transmission,suggesting that zikv may result in severe neurologic complications. © 2017 the library of science. all rights reserved.
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آدرس
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national center for emerging zoonotic and infectious diseases,division of high-consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga, United States, program for control and prevention of malaria and diseases transmitted by aedes ministry of health,federal district,brasília, Brazil, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, department of communicable disease surveillance ministry of health,federal district,brasília, Brazil, department of communicable disease surveillance ministry of health,federal district,brasília, Brazil, department of communicable disease surveillance ministry of health,federal district,brasília, Brazil, national center for immunization and respiratory diseases,division of viral diseases,centers for disease control and prevention,atlanta,ga, United States, program for control and prevention of malaria and diseases transmitted by aedes ministry of health,federal district,brasília, Brazil, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of vector-borne diseases,centers for disease control and prevention,fort collins,co, United States, national center for emerging zoonotic and infectious diseases,division of high-consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga, United States, national center for emerging zoonotic and infectious diseases,division of high-consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga, United States, national center for hiv/aids,viral hepatitis,std and tb prevention,division of tuberculosis elimination,centers for disease control and prevention,atlanta,ga, United States, federal university of bahia,complexo hospitalar edgard santos,salvador,bahia, Brazil, national center for emerging zoonotic and infectious diseases,division of high-consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga, United States, department of communicable disease surveillance ministry of health,federal district,brasília, Brazil
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