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Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer
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نویسنده
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en j. ,kitamoto s. ,kawashima a. ,yonezawa s. ,kishi y. ,ishii n. ,goto m.
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منبع
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plos neglected tropical diseases - 2017 - دوره : 11 - شماره : 8
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چکیده
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Buruli ulcer is a chronic painless skin disease caused by mycobacterium ulcerans. the local nerve damage induced by m. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a buruli ulcer mouse model. in order to elucidate the mechanism of this nerve damage,we tested and compared the cytotoxic effect of synthetic mycolactone a/b on cultured schwann cells,fibroblasts and macrophages. mycolactone induced much higher cell death and apoptosis in schwann cell line sw10 than in fibroblast line l929. these results suggest that mycolactone is a key substance in the production of nerve damage of buruli ulcer. © 2017 en et al.
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آدرس
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department of pathology,kagoshima university,kagoshima,japan,national sanatorium hoshizuka-keiaien,kanoya,kagoshima,japan,international university of health and welfare,narita,chiba, Japan, department of pathology,kagoshima university,kagoshima,japan,division of gastroenterology,department of internal medicine,university of michigan medical school,ann arbor,mi, United States, department of clinical laboratory science,faculty of medical technology,teikyo university,itabashi,tokyo, Japan, department of pathology,kagoshima university,kagoshima, Japan, department of chemistry and chemical biology,harvard university,boston,ma, United States, leprosy research center,national institute of infectious diseases,higashimurayama,tokyo, Japan, department of pathology,kagoshima university,kagoshima,japan,national sanatorium hoshizuka-keiaien,kanoya,kagoshima, Japan
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Authors
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