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Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome,Xinyang,China
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نویسنده
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liu k. ,cui n. ,fang l.-q. ,wang b.-j. ,lu q.-b. ,peng w. ,li h. ,wang l.-y. ,liang s. ,wang h.-y. ,zhang y.-y. ,zhuang l. ,yang h. ,gray g.c. ,de vlas s.j. ,liu w. ,cao w.-c.
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منبع
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plos neglected tropical diseases - 2014 - دوره : 8 - شماره : 5
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چکیده
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Background:severe fever with thrombocytopenia syndrome (sfts) is an emerging infectious disease discovered in rural areas of central china in 2009,caused by a novel bunyavirus,sfts virus (sftsv). the disease usually presents as fever,thrombocytopenia,and leukocytopenia,with case-fatality rates ranging from 2.5% to 30%. haemaphysalis longicornis was suspected to be the most likely vector of sftsv. by the end of 2012,the disease had expanded to 13 provinces of china. sfts patients have been reported in japan and south korea,and a disease similar to sfts has been reported in the united states.methodology/principal findings:we characterized the epidemiologic features of 504 confirmed sfts cases in xinyang region,the most severely sfts-afflicted region in china from 2011 to 2012,and assessed the environmental risk factors. all cases occurred during march to november,with the epidemic peaking from may to july. the patients' ages ranged from 7 to 87 years (median 61 years),and the annual incidence increased with age (χ2 test for trend,p<0.001). the female-to-male ratio of cases was 1.58,and 97.0% of the cases were farmers who resided in the southern and western parts of the region. the poisson regression analysis revealed that the spatial variations of sfts incidence were significantly associated with the shrub,forest,and rain-fed cropland areas.conclusions:the distribution of sfts showed highly significant temporal and spatial heterogeneity in xinyang region,with the majority of sfts cases being elderly farmers who resided in the southern and western parts of the region,mostly acquiring infection between may and july when h. longicornis is highly active. the shrub,rain-fed,and rain-fed cropland areas were associated with high risk for this disease. © 2014 liu et al.
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آدرس
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state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, the 154 hospital,people's liberation army,xinyang, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, the 154 hospital,people's liberation army,xinyang, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, the shangcheng people's hospital,shangcheng, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing,china,anhui medical university,hefei, China, environmental and global health,college of public health and health professions,and emerging pathogens institute,university of florida,gainesville,fl, United States, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing,china,anhui medical university,hefei, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing,china,anhui medical university,hefei, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, environmental and global health,college of public health and health professions,and emerging pathogens institute,university of florida,gainesville,fl, United States, department of public health,erasmus mc,university medical center rotterdam,rotterdam, Netherlands, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China
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Authors
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