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Efficacy and Safety of Praziquantel,Tribendimidine and Mebendazole in Patients with Co-infection of Clonorchis sinensis and Other Helminths
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نویسنده
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xu l.-l. ,jiang b. ,duan j.-h. ,zhuang s.-f. ,liu y.-c. ,zhu s.-q. ,zhang l.-p. ,zhang h.-b. ,xiao s.-h. ,zhou x.-n.
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منبع
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plos neglected tropical diseases - 2014 - دوره : 8 - شماره : 8
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چکیده
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Background: both tribendimidine and mebendazole are broad-spectrum drugs for anti-intestinal nematodes. we aim to assess the efficacy and safety of tribendimidine and mebendazole in patients with co-infection of clonorchis sinensis and other helminths. method: we performed a randomized open-label trial in qiyang,people's republic of china. eligible participants were randomly assigned to one of four groups: (i) a single dose of 400 mg tribendimidine,(ii) 200 mg tribendimidine twice daily,(iii) 75 mg/kg praziquantel divided in four doses within 2 days,and (iv) a single dose of 400 mg mebendazole. cure rates and egg reduction rates were assessed,and adverse events were monitored after treatments. uncured patients accepted the second treatment with the same drugs after the first treatment. results: 156 patients were eligible for the study. results from the first treatment showed that the cure rates of single-dose tribendimidine and praziquantel against c. sinensis were 50% and 56.8%,respectively; the single-dose tribendimidine achieved the cure rate of 77.8% in the treatment for hookworm,which was significantly higher than that of praziquantel; low cure rates were obtained in the treatment of single-dose tribendimidine against ascaris lumbricoides and trichuris trichiura (28.6% and 23.1%). results of the second treatment illustrated the cure rates of tribendimidine and praziquantel against c. sinensis were 78.1% and 75%,respectively. most adverse events were mild and transient. adverse events caused by tribendimidine were significantly less than praziquantel. conclusion: single-dose tribendimidine showed similar efficacy against c. sinensis as praziquantel with less adverse events,and achieved significantly higher cure rate in the treatment for hookworm than those of praziquantel and mebendazole. low cure rates,which were still higher than other drugs,were obtained in the treatment of single-dose tribendimidine against ascaris lumbricoides and trichuris trichiura. trial registration: controlled-trials.com isrctn55086560 © 2014 xu et al.
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آدرس
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national institute of parasitic diseases,chinese center for disease control and prevention,shanghai,china,who collaborative center for malaria,schistosomiasis and filariasis,key laboratory of parasite and vector biology,ministry of health,shanghai, China, national institute of parasitic diseases,chinese center for disease control and prevention,shanghai,china,who collaborative center for malaria,schistosomiasis and filariasis,key laboratory of parasite and vector biology,ministry of health,shanghai, China, hunan center for disease control and prevention,changsha, China, hunan center for disease control and prevention,changsha, China, qiyang center for disease control and prevention,yongzhou, China, qiyang center for disease control and prevention,yongzhou, China, sichuan center for disease control and prevention,chengdu, China, national institute of parasitic diseases,chinese center for disease control and prevention,shanghai,china,who collaborative center for malaria,schistosomiasis and filariasis,key laboratory of parasite and vector biology,ministry of health,shanghai, China, national institute of parasitic diseases,chinese center for disease control and prevention,shanghai,china,who collaborative center for malaria,schistosomiasis and filariasis,key laboratory of parasite and vector biology,ministry of health,shanghai, China, national institute of parasitic diseases,chinese center for disease control and prevention,shanghai,china,who collaborative center for malaria,schistosomiasis and filariasis,key laboratory of parasite and vector biology,ministry of health,shanghai, China
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Authors
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