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Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
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نویسنده
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amza a. ,yu s.n. ,kadri b. ,nassirou b. ,stoller n.e. ,zhou z. ,west s.k. ,bailey r.l. ,gaynor b.d. ,keenan j.d. ,porco t.c. ,lietman t.m.
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منبع
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plos neglected tropical diseases - 2014 - دوره : 8 - شماره : 9
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چکیده
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Background: antibiotic use on animals demonstrates improved growth regardless of whether or not there is clinical evidence of infectious disease. antibiotics used for trachoma control may play an unintended benefit of improving child growth. methodology: in this sub-study of a larger randomized controlled trial,we assess anthropometry of pre-school children in a community-randomized trial of mass oral azithromycin distributions for trachoma in niger. we measured height,weight,and mid-upper arm circumference (muac) in 12 communities randomized to receive annual mass azithromycin treatment of everyone versus 12 communities randomized to receive biannual mass azithromycin treatments for children,3 years after the initial mass treatment. we collected measurements in 1,034 children aged 6–60 months of age. principal findings: we found no difference in the prevalence of wasting among children in the 12 annually treated communities that received three mass azithromycin distributions compared to the 12 biannually treated communities that received six mass azithromycin distributions (odds ratio = 0.88,95% confidence interval = 0.53 to 1.49). conclusions/significance: we were unable to demonstrate a statistically significant difference in stunting,underweight,and low muac of pre-school children in communities randomized to annual mass azithromycin treatment or biannual mass azithromycin treatment. the role of antibiotics on child growth and nutrition remains unclear,but larger studies and longitudinal trials may help determine any association. © 2014 amza et al.
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آدرس
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programme fss/université abdou moumouni de niamey,programme national de santé oculaire,niamey, Niger, f.i. proctor foundation,university of california san francisco,san francisco,ca, United States, programme fss/université abdou moumouni de niamey,programme national de santé oculaire,niamey, Niger, programme fss/université abdou moumouni de niamey,programme national de santé oculaire,niamey, Niger, f.i. proctor foundation,university of california san francisco,san francisco,ca, United States, f.i. proctor foundation,university of california san francisco,san francisco,ca, United States, dana center for preventive ophthalmology,wilmer eye institute,johns hopkins university,baltimore,md, United States, clinical research unit,department of infectious and tropical diseases,london school of hygiene and tropical medicine,london, United Kingdom, f.i. proctor foundation,university of california san francisco,san francisco,ca,united states,department of ophthalmology,university of california san francisco,san francisco,ca, United States, f.i. proctor foundation,university of california san francisco,san francisco,ca,united states,department of ophthalmology,university of california san francisco,san francisco,ca, United States, f.i. proctor foundation,university of california san francisco,san francisco,ca,united states,department of epidemiology & biostatistics,university of california san francisco,san francisco,ca,united states,institute for global health,university of california,san francisco,ca, United States, f.i. proctor foundation,university of california san francisco,san francisco,ca,united states,department of ophthalmology,university of california san francisco,san francisco,ca,united states,department of epidemiology & biostatistics,university of california san francisco,san francisco,ca,united states,institute for global health,university of california,san francisco,ca, United States
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Authors
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