Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

Invasion of the central nervous system (cns) by african trypanosomes represents a critical step in the development of human african trypanosomiasis. in both clinical cases and experimental mouse infections it has been demonstrated that predisposition to cns invasion is associated with a type 1 systemic inflammatory response. using the trypanosoma brucei brucei gvr35 experimental infection model,we demonstrate that systemic delivery of the counter-inflammatory cytokine il-10 lowers plasma ifn-γ and tnf-α concentrations,cns parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. the results provide evidence that cns invasion may be susceptible to immunological attenuation. © 2015 rodgers et al.