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HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: Implications for progression to neurological complications
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نویسنده
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ndhlovu l.c. ,leal f.e. ,hasenkrug a.m. ,jha a.r. ,carvalho k.i. ,eccles-james i.g. ,bruno f.r. ,vieira r.g.s. ,york v.a. ,chew g.m. ,jones r.b. ,tanaka y. ,neto w.k. ,sanabani s.s. ,ostrowski m.a. ,segurado a.c. ,nixon d.f. ,kallas e.g.
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منبع
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plos neglected tropical diseases - 2011 - دوره : 5 - شماره : 4
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چکیده
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The t cell immunoglobulin mucin 3 (tim-3) receptor is highly expressed on hiv-1-specific t cells,rendering them partially exhausted and unable to contribute to the effective immune mediated control of viral replication. to elucidate novel mechanisms contributing to the htlv-1 neurological complex and its classic neurological presentation called ham/tsp (htlv-1 associated myelopathy/tropical spastic paraparesis),we investigated the expression of the tim-3 receptor on cd8+ t cells from a cohort of htlv-1 seropositive asymptomatic and symptomatic patients. patients diagnosed with ham/tsp down-regulated tim-3 expression on both cd8+ and cd4+ t cells compared to asymptomatic patients and htlv-1 seronegative controls. htlv-1 tax-specific,hla-a*02 restricted cd8+ t cells among ham/tsp individuals expressed markedly lower levels of tim-3. we observed tax expressing cells in both tim-3+ and tim-3- fractions. taken together,these data indicate that there is a systematic downregulation of tim-3 levels on t cells in htlv-1 infection,sustaining a profoundly highly active population of potentially pathogenic t cells that may allow for the development of htlv-1 complications. © 2011 ndhlovu et al.
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آدرس
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division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of clinical immunology and allergy,department of infectious diseases,school of medicine,university of são paulo,são paulo,brazil,department of infectious diseases,school of medicine,university of são paulo,são paulo, Brazil, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of clinical immunology and allergy,department of infectious diseases,school of medicine,university of são paulo,são paulo, Brazil, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of clinical immunology and allergy,department of infectious diseases,school of medicine,university of são paulo,são paulo, Brazil, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, department of immunology,university of toronto,toronto,on, Canada, department of immunology,university of the ryukyus,okinawa, Japan, molecular biology laboratory,fundação pró-sangue,hemocentro de são paulo,são paulo, Brazil, molecular biology laboratory,fundação pró-sangue,hemocentro de são paulo,são paulo, Brazil, department of immunology,university of toronto,toronto,on, Canada, department of infectious diseases,school of medicine,university of são paulo,são paulo, Brazil, division of experimental medicine,department of medicine,university of california san francisco,san francisco,ca, United States, division of clinical immunology and allergy,department of infectious diseases,school of medicine,university of são paulo,são paulo,brazil,department of infectious diseases,school of medicine,university of são paulo,são paulo, Brazil
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Authors
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