>
Fa   |   Ar   |   En
   Foxp3 and IL-10 expression correlates with parasite burden in lesional tissues of post kala azar dermal leishmaniasis (PKDL) patients  
   
نویسنده katara g.k. ,ansari n.a. ,verma s. ,ramesh v. ,salotra p.
منبع plos neglected tropical diseases - 2011 - دوره : 5 - شماره : 5
چکیده    Background: post kala-azar dermal leishmaniasis (pkdl),a sequel to visceral leishamaniasis (vl) in 5-15% cases,constitutes a parasite reservoir important in disease transmission. the precise immunological cause of pkdl outcome remains obscure. however,overlapping counter regulatory responses with elevated ifn-γ and il-10 are reported. methodology/principal findings: present study deals with ex-vivo mrna and protein analysis of natural regulatory t cells (ntreg) markers (foxp3,cd25 and ctla-4) and il-10 levels in lesion tissues of pkdl patients at pre and post treatment stages. in addition,correlation of ntreg markers and il-10 with parasite load in tissue lesions was investigated. mrna levels of ntreg markers and il-10 were found significantly elevated in pre-treatment pkdl cases compared to controls (foxp3,p = 0.0009; cd25 & ctla-4,p<0.0001; il-10,p<0.0001),and were restored after treatment. analysis of ntreg cell markers and il-10 in different clinical manifestations of disease revealed elevated levels in nodular lesions compared to macules/papules. further,foxp3,cd25 and il-10 mrna levels directly correlated with parasite load in lesions tissues. conclusion/significance: data demonstrated accumulation of ntreg cells in infected tissue and a correlation of both il-10 and ntreg levels with parasite burden suggesting their role in disease severity in pkdl. © 2011 katara et al.
آدرس institute of pathology (icmr),safdarjung hospital campus,new delhi, India, institute of pathology (icmr),safdarjung hospital campus,new delhi,india,laboratory of parasitic diseases,national institutes of allergy and infectious diseases,national institutes of health,bethesda,md, United States, institute of pathology (icmr),safdarjung hospital campus,new delhi, India, department of dermatology,safdarjung hospital,new delhi, India, institute of pathology (icmr),safdarjung hospital campus,new delhi, India
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved