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Inflammatory cytokine expression is associated with Chikungunya virus resolution and symptom severity
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نویسنده
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kelvin a.a. ,banner d. ,silvi g. ,moro m.l. ,spataro n. ,gaibani p. ,cavrini f. ,pierro a. ,rossini g. ,cameron m.j. ,bermejo-martin j.f. ,paquette s.g. ,xu l. ,danesh a. ,farooqui a. ,borghetto i. ,kelvin d.j. ,sambri v. ,rubino s.
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منبع
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plos neglected tropical diseases - 2011 - دوره : 5 - شماره : 8
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چکیده
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The chikungunya virus infection zones have now quickly spread from africa to parts of asia,north america and europe. originally thought to trigger a disease of only mild symptoms,recently chikungunya virus caused large-scale fatalities and widespread economic loss that was linked to recent virus genetic mutation and evolution. due to the paucity of information on chikungunya immunological progression,we investigated the serum levels of 13 cytokines/chemokines during the acute phase of chikungunya disease and 6- and 12-month post-infection follow-up from patients of the italian outbreak. we found that cxcl9/mig,ccl2/mcp-1,il-6 and cxcl10/ip-10 were significantly raised in the acute phase compared to follow-up samples. furthermore,il-1β,tnf-α,il-12,il-10,ifn-γ and il-5 had low initial acute phase levels that significantly increased at later time points. analysis of symptom severity showed association with cxcl9/mig,cxcl10/ip-10 and igg levels. these data give insight into chikungunya disease establishment and subsequent convalescence,which is imperative to the treatment and containment of this quickly evolving and frequently re-emerging disease. © 2011 kelvin et al.
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آدرس
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sardinia research and development (sard),university di sassari,sassari,italy,immune diagnostics and research (idr),toronto medical discovery tower (tdmt),toronto,on, Canada, experimental therapeutics,university health network (uhn),toronto,on, Canada, dipartimento di sanità pubblica,azienda usl di ravenna,ferrara, Italy, agenzia sanitaria e sociale regione emilia-romagna,bologna, Italy, department of hematology and oncology,alma mater studiorum - university of bologna,bologna, Italy, department of hematology and oncology,alma mater studiorum - university of bologna,bologna, Italy, department of hematology and oncology,alma mater studiorum - university of bologna,bologna, Italy, department of hematology and oncology,alma mater studiorum - university of bologna,bologna, Italy, department of hematology and oncology,alma mater studiorum - university of bologna,bologna, Italy, experimental therapeutics,university health network (uhn),toronto,on, Canada, national centre of influenza,hospital clínico universitario de valladolid,valladolid,spain,unidad de investigación en infección e inmunidad - microbiology service,hospital clínico universitario de valladolid,instituto de estudios de ciencias de la salud de castilla y león (iecscyl),valladolid, Spain, experimental therapeutics,university health network (uhn),toronto,on,canada,faculty of medicine,institute of medical science (ims),university of toronto,toronto,on, Canada, experimental therapeutics,university health network (uhn),toronto,on, Canada, experimental therapeutics,university health network (uhn),toronto,on, Canada, sardinia research and development (sard),university di sassari,sassari, Italy, sardinia research and development (sard),university di sassari,sassari,italy,dipartimento di scienze biomediche,university di sassari,sassari, Italy, experimental therapeutics,university health network (uhn),toronto,on,canada,faculty of medicine,institute of medical science (ims),university of toronto,toronto,on,canada,phd school in biomolecular and biotechnology sciences,university of sassari,sassari, Italy, department of hematology and oncology,alma mater studiorum - university of bologna,bologna, Italy, sardinia research and development (sard),university di sassari,sassari,italy,dipartimento di scienze biomediche,university di sassari,sassari, Italy
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Authors
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