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First report of sylvatic DENV-2-associated dengue hemorrhagic fever in West Africa
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نویسنده
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franco l. ,palacios g. ,martinez j.a. ,vázquez a. ,savji n. ,de ory f. ,sanchez-seco m.p. ,martín d. ,lipkin w.i. ,tenorio a.
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منبع
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plos neglected tropical diseases - 2011 - دوره : 5 - شماره : 8
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چکیده
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Dengue virus (denv) circulates in human and sylvatic cycles. sylvatic strains are both ecologically and evolutionarily distinct from endemic viruses. although sylvatic dengue cycles occur in west african countries and malaysia,only a few cases of mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in malaysia have been reported. here we report a case of dengue hemorrhagic fever (dhf) with thrombocytopenia (13000/μl),a raised hematocrit (32% above baseline) and mucosal bleeding in a 27-year-old male returning to spain in november 2009 after visiting his home country guinea bissau. sylvatic denv-2 west african lineage was isolated from blood and sera. this is the first case of dhf associated with sylvatic denv-2 in africa and the second case worldwide of dhf caused by a sylvatic strain. © 2011 franco et al.
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آدرس
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national center for microbiology,instituto de salud carlos iii,majadahonda,madrid, Spain, center for infection and immunity,mailman school of public health,columbia university,new york,ny, United States, hospital infanta cristina,parla,madrid, Spain, national center for microbiology,instituto de salud carlos iii,majadahonda,madrid, Spain, center for infection and immunity,mailman school of public health,columbia university,new york,ny, United States, national center for microbiology,instituto de salud carlos iii,majadahonda,madrid, Spain, national center for microbiology,instituto de salud carlos iii,majadahonda,madrid, Spain, laboratorio br salud,san sebastián de los reyes,madrid, Spain, center for infection and immunity,mailman school of public health,columbia university,new york,ny, United States, national center for microbiology,instituto de salud carlos iii,majadahonda,madrid, Spain
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Authors
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