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Molecular investigations of a locally acquired case of melioidosis in Southern AZ,USA
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نویسنده
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engelthaler d.m. ,bowers j. ,schupp j.a. ,pearson t. ,ginther j. ,hornstra h.m. ,dale j. ,stewart t. ,sunenshine r. ,waddell v. ,levy c. ,gillece j. ,price l.b. ,contente t. ,beckstrom-sternberg s.m. ,blaney d.d. ,wagner d.m. ,mayo m. ,currie b.j. ,keim p. ,tuanyok a.
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منبع
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plos neglected tropical diseases - 2011 - دوره : 5 - شماره : 10
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چکیده
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Melioidosis is caused by burkholderia pseudomallei,a gram-negative bacillus,primarily found in soils in southeast asia and northern australia. a recent case of melioidosis in non-endemic arizona was determined to be the result of locally acquired infection,as the patient had no travel history to endemic regions and no previous history of disease. diagnosis of the case was confirmed through multiple microbiologic and molecular techniques. to enhance the epidemiological analysis,we conducted several molecular genotyping procedures,including multi-locus sequence typing,snp-profiling,and whole genome sequence typing. each technique has different molecular epidemiologic advantages,all of which provided evidence that the infecting strain was most similar to those found in southeast asia,possibly originating in,or around,malaysia. advancements in new typing technologies provide genotyping resolution not previously available to public health investigators,allowing for more accurate source identification.
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آدرس
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translational genomics research institute,flagstaff,az, United States, translational genomics research institute,flagstaff,az, United States, translational genomics research institute,flagstaff,az, United States, northern arizona university,flagstaff,az, United States, northern arizona university,flagstaff,az, United States, northern arizona university,flagstaff,az, United States, northern arizona university,flagstaff,az, United States, arizona department of health services,phoenix,az, United States, arizona department of health services,phoenix,az,united states,centers for disease control and prevention,atlanta,ga, United States, arizona department of health services,phoenix,az, United States, arizona department of health services,phoenix,az, United States, translational genomics research institute,flagstaff,az, United States, translational genomics research institute,flagstaff,az, United States, translational genomics research institute,flagstaff,az, United States, translational genomics research institute,flagstaff,az,united states,northern arizona university,flagstaff,az, United States, centers for disease control and prevention,atlanta,ga, United States, northern arizona university,flagstaff,az, United States, menzies school of health research,darwin,nt, Australia, menzies school of health research,darwin,nt, Australia, translational genomics research institute,flagstaff,az,united states,northern arizona university,flagstaff,az, United States, northern arizona university,flagstaff,az, United States
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Authors
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