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Integrated dataset of screening hits against multiple neglected disease pathogens
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نویسنده
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nwaka s. ,besson d. ,ramirez b. ,maes l. ,matheeussen a. ,bickle q. ,mansour n.r. ,yousif f. ,townson s. ,gokool s. ,cho-ngwa f. ,samje m. ,misra-bhattacharya s. ,murthy p.k. ,fakorede f. ,paris j.-m. ,yeates c. ,ridley r. ,van voorhis w.c. ,geary t.
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منبع
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plos neglected tropical diseases - 2011 - دوره : 5 - شماره : 12
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چکیده
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New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744hits. we discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative,multi-pathogen approach. © 2011 nwaka et al. this is an open-access article distributed under the terms of the creative commons attribution license,which permits unrestricted use,distribution,and reproduction in any medium,provided the original author and source are credited.
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آدرس
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special programme for research and training in tropical diseases,world health organization,geneva,switzerland,african network for drugs and diagnostics innovation,united nations economic commission for africa,addis ababa, Ethiopia, special programme for research and training in tropical diseases,world health organization,geneva, Switzerland, special programme for research and training in tropical diseases,world health organization,geneva, Switzerland, university of antwerp,antwerp, Belgium, university of antwerp,antwerp, Belgium, london school of hygiene and tropical medicine,london, United Kingdom, london school of hygiene and tropical medicine,london, United Kingdom, theodor bilharz research institute,cairo, Egypt, northwick park institute for medical research,harrow, United Kingdom, northwick park institute for medical research,harrow, United Kingdom, university of buea,buea, Cameroon, university of buea,buea, Cameroon, central drug research institute,lucknow, India, central drug research institute,lucknow, India, special programme for research and training in tropical diseases,world health organization,geneva,switzerland,african network for drugs and diagnostics innovation,united nations economic commission for africa,addis ababa, Ethiopia, ecole nationale supérieure de chimie de paris,paris, France, inpharma consultancy,herts, United Kingdom, special programme for research and training in tropical diseases,world health organization,geneva, Switzerland, university of washington,seattle,wa, United States, mcgill university,montreal, Canada
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Authors
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