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Clear genetic distinctiveness between human- and pig-derived trichuris based on analyses of mitochondrial datasets
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نویسنده
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liu g.-h. ,gasser r.b. ,su a. ,nejsum p. ,peng l. ,lin r.-q. ,li m.-w. ,xu m.-j. ,zhu x.-q.
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منبع
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plos neglected tropical diseases - 2012 - دوره : 6 - شماره : 2
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چکیده
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The whipworm,trichuris trichiura,causes trichuriasis in ~600 million people worldwide,mainly in developing countries. whipworms also infect other animal hosts,including pigs (t. suis),dogs (t. vulpis) and non-human primates,and cause disease in these hosts,which is similar to trichuriasis of humans. although trichuris species are considered to be host specific,there has been considerable controversy,over the years,as to whether t. trichiura and t. suis are the same or distinct species. here,we characterised the entire mitochondrial genomes of human-derived trichuris and pig-derived trichuris,compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. taken together,the findings support the proposal that t. trichiura and t. suis are separate species,consistent with previous data for nuclear ribosomal dna. using molecular analytical tools,employing genetic markers defined herein,future work should conduct large-scale studies to establish whether t. trichiura is found in pigs and t. suis in humans in endemic regions. © 2012 liu et al.
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آدرس
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state key laboratory of veterinary etiological biology,key laboratory of veterinary parasitology of gansu province,lanzhou veterinary research institute,chinese academy of agricultural sciences,lanzhou,gansu province,china,college of veterinary medicine,hunan agricultural university,changsha,hunan province, China, department of veterinary science,the university of melbourne,werribee,vic, Australia, state key laboratory of veterinary etiological biology,key laboratory of veterinary parasitology of gansu province,lanzhou veterinary research institute,chinese academy of agricultural sciences,lanzhou,gansu province,china,college of veterinary medicine,south china agricultural university,guangzhou,guangdong province, China, departments of veterinary disease biology and basic animal and veterinary science,university of copenhagen,frederiksberg, Denmark, department of parasitology and clinical parasitology,guangdong medical college,zhanjiang,guangdong province, China, college of veterinary medicine,south china agricultural university,guangzhou,guangdong province, China, department of veterinary medicine,agricultural college,guangdong ocean university,zhanjiang,guangdong province, China, state key laboratory of veterinary etiological biology,key laboratory of veterinary parasitology of gansu province,lanzhou veterinary research institute,chinese academy of agricultural sciences,lanzhou,gansu province, China, state key laboratory of veterinary etiological biology,key laboratory of veterinary parasitology of gansu province,lanzhou veterinary research institute,chinese academy of agricultural sciences,lanzhou,gansu province,china,college of veterinary medicine,hunan agricultural university,changsha,hunan province,china,college of animal science and veterinary medicine,heilongjiang bayi agricultural university,daqing,heilongjiang province, China
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Authors
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