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Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam
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نویسنده
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gray d.j. ,thrift a.p. ,williams g.m. ,zheng f. ,li y.-s. ,guo j. ,chen h. ,wang t. ,xu x.j. ,zhu r. ,zhu h. ,cao c.l. ,da lin d. ,zhao z.y. ,li r.s. ,davis g.m. ,mcmanus d.p.
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منبع
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plos neglected tropical diseases - 2012 - دوره : 6 - شماره : 4
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چکیده
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Background: schistosoma japonicum is a major public health concern in the peoples' republic of china (prc),with about 800,000 people infected and another 50 million living in areas at risk of infection. based on ecological,environmental,population genetic and molecular factors,schistosomiasis transmission in prc can be categorised into four discrete ecosystems or transmission modes. it is predicted that,long-term,the three gorges dam (tgd) will impact upon the transmission of schistosomiasis in the prc,with varying degree across the four transmission modes. methodology/principal findings: we undertook longitudinal surveillance from 2002 to 2006 in sentinel villages of the three transmission modes below the tgd across four provinces (hunan,jiangxi,hubei and anhui) to determine whether there was any immediate impact of the tgd on schistosomiasis transmission. eight sentinel villages were selected to represent both province and transmission mode. the primary end point measured was human incidence. here we present the results of this five-year longitudinal cohort study. results showed that the incidence of human s. japonicum infection declined considerably within individual villages and overall mode over the course of the study. this is also reflected in the yearly odds ratios (adjusted) for infection risk that showed significant (p<0.01) downward trends in all modes over the follow-up period. conclusions/significance: the decrease in human s. japonicum incidence observed across all transmission modes in this study can probably be attributed to the annual human and bovine pzq chemotherapy. if an increase in schistosome transmission had occurred as a result of the tgd,it would be of negligible size compared to the treatment induced decline seen here. it appears therefore that there has been virtually no immediate impact of the tgd on schistosomiasis transmission downstream of the dam. © 2012 gray et al.
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آدرس
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molecular parasitology laboratory,infectious diseases division,queensland institute of medical research,herston,brisbane,qld,australia,griffith health institute,griffith university,meadowbrook,qld,australia,school of population health,university of queensland,brisbane,qld, Australia, school of population health,university of queensland,brisbane,qld,australia,cancer control group,queensland institute of medical research,brisbane,qld, Australia, school of population health,university of queensland,brisbane,qld, Australia, national institute of parasitic disease,chinese centre for disease control and prevention,shanghai, China, molecular parasitology laboratory,infectious diseases division,queensland institute of medical research,herston,brisbane,qld,australia,hunan institute of parasitic diseases,world health org. collaborating centre for research and control on schistosomiasis in lake region,yueyang, China, national institute of parasitic disease,chinese centre for disease control and prevention,shanghai, China, jiangxi provincial institute of parasitic diseases,nanchang, China, anhui institute for schistosomiasis control,hefei, China, hubei institute for schistosomiasis control,wuhan, China, national institute of parasitic disease,chinese centre for disease control and prevention,shanghai, China, national institute of parasitic disease,chinese centre for disease control and prevention,shanghai, China, national institute of parasitic disease,chinese centre for disease control and prevention,shanghai, China, jiangxi provincial institute of parasitic diseases,nanchang, China, hunan institute of parasitic diseases,world health org. collaborating centre for research and control on schistosomiasis in lake region,yueyang, China, griffith health institute,griffith university,meadowbrook,qld,australia,school of population health,university of queensland,brisbane,qld, Australia, department of microbiology and tropical medicine,george washington university medical centre,washington d.c., United States, griffith health institute,griffith university,meadowbrook,qld, Australia
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Authors
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