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IFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strain
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نویسنده
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rodrigues a.a. ,saosa j.s.s. ,da silva g.k. ,martins f.a. ,da silva a.a. ,da silva souza neto c.p. ,horta c.v. ,zamboni d.s. ,da silva j.s. ,ferro e.a.v. ,da silva c.v.
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منبع
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plos neglected tropical diseases - 2012 - دوره : 6 - شماره : 4
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چکیده
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Background: t. cruzi strains have been divided into six discrete typing units (dtus) according to their genetic background. these groups are designated t. cruzi i to vi. in this context,amastigotes from g strain (t. cruzi i) are highly infective in vitro and show no parasitemia in vivo. here we aimed to understand why amastigotes from g strain are highly infective in vitro and do not contribute for a patent in vivo infection. methodology/principal findings: our in vitro studies demonstrated the first evidence that ifn-γ would be associated to the low virulence of g strain in vivo. after intraperitoneal amastigotes inoculation in wild-type and knockout mice for tnf-α,nod2,myd88,inos,il-12p40,il-18,cd4,cd8 and ifn-γ we found that the latter is crucial for controlling infection by g strain amastigotes. conclusions/significance: our results showed that amastigotes from g strain are highly infective in vitro but did not contribute for a patent infection in vivo due to its susceptibility to ifn-γ production by host immune cells. these data are useful to understand the mechanisms underlying the contrasting behavior of different t. cruzi groups for in vitro and in vivo infection. © 2012 rodrigues et al.
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آدرس
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instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,minas gerais, Brazil, departamento de bioquímica e imunologia,universidade de são paulo,ribeirão preto,são paulo,brazil,universidad autónoma de bucaramanga,bucaramanga, Colombia, departamento de bioquímica e imunologia,universidade de são paulo,ribeirão preto,são paulo, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,minas gerais, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,minas gerais, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,minas gerais, Brazil, departamento de biologia celular,universidade de são paulo,ribeirão preto,são paulo, Brazil, departamento de biologia celular,universidade de são paulo,ribeirão preto,são paulo, Brazil, departamento de bioquímica e imunologia,universidade de são paulo,ribeirão preto,são paulo, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,minas gerais, Brazil, instituto de ciências biomédicas,universidade federal de uberlândia,uberlândia,minas gerais, Brazil
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Authors
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