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Neutrophil paralysis in plasmodium vivax malaria
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نویسنده
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de leoratti f.m.s. ,trevelin s.c. ,cunha f.q. ,rocha b.c. ,costa p.a.c. ,gravina h.d. ,tada m.s. ,pereira d.b. ,golenbock d.t. ,do valle antonelli l.r. ,gazzinelli r.t.
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منبع
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plos neglected tropical diseases - 2012 - دوره : 6 - شماره : 6
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چکیده
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Background: the activation of innate immune responses by plasmodium vivax results in activation of effector cells and an excessive production of pro-inflammatory cytokines that may culminate in deleterious effects. here,we examined the activation and function of neutrophils during acute episodes of malaria. materials and methods: blood samples were collected from p. vivax-infected patients at admission (day 0) and 30-45 days after treatment with chloroquine and primaquine. expression of activation markers and cytokine levels produced by highly purified monocytes and neutrophils were measured by the cytometric bead assay. phagocytic activity,superoxide production,chemotaxis and the presence of g protein-coupled receptor (grk2) were also evaluated in neutrophils from malaria patients. principal findings: both monocytes and neutrophils from p. vivax-infected patients were highly activated. while monocytes were found to be the main source of cytokines in response to tlr ligands,neutrophils showed enhanced phagocytic activity and superoxide production. interestingly,neutrophils from the malaria patients expressed high levels of grk2,low levels of cxcr2,and displayed impaired chemotaxis towards il-8 (cxcl8). conclusion: activated neutrophils from malaria patients are a poor source of pro-inflammatory cytokines and display reduced chemotactic activity,suggesting a possible mechanism for an enhanced susceptibility to secondary bacterial infection during malaria. © 2012 leoratti et al.
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آدرس
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laboratório de imunopatologia,centro de pesquisas rené rachou,fundação oswaldo cruz,belo horizonte,minas gerais, Brazil, departamento de farmacologia,faculdade de medicina de ribeirão preto,universidade de são paulo,ribeirão preto,são paulo, Brazil, departamento de farmacologia,faculdade de medicina de ribeirão preto,universidade de são paulo,ribeirão preto,são paulo, Brazil, laboratório de imunopatologia,centro de pesquisas rené rachou,fundação oswaldo cruz,belo horizonte,minas gerais,brazil,departamento de bioquímica e imunologia,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, laboratório de imunopatologia,centro de pesquisas rené rachou,fundação oswaldo cruz,belo horizonte,minas gerais, Brazil, laboratório de imunopatologia,centro de pesquisas rené rachou,fundação oswaldo cruz,belo horizonte,minas gerais,brazil,departamento de bioquímica e imunologia,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, centro de pesquisas em medicina tropical de rondônia,porto velho,rondônia, Brazil, centro de pesquisas em medicina tropical de rondônia,porto velho,rondônia, Brazil, division of infectious diseases and immunology,university of massachusetts medical school,worcester,ma, United States, laboratório de imunopatologia,centro de pesquisas rené rachou,fundação oswaldo cruz,belo horizonte,minas gerais, Brazil, laboratório de imunopatologia,centro de pesquisas rené rachou,fundação oswaldo cruz,belo horizonte,minas gerais,brazil,departamento de bioquímica e imunologia,universidade federal de minas gerais,belo horizonte,minas gerais,brazil,division of infectious diseases and immunology,university of massachusetts medical school,worcester,ma, United States
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Authors
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