|
|
|
|
Microproteinuria during Opisthorchis viverrini Infection: A Biomarker for Advanced Renal and Hepatobiliary Pathologies from Chronic Opisthorchiasis
|
|
|
|
|
|
|
|
نویسنده
|
saichua p. ,sithithaworn p. ,jariwala a.r. ,deimert d.j. ,sithithaworn j. ,sripa b. ,laha t. ,mairiang e. ,pairojkul c. ,periago m.v. ,khuntikeo n. ,mulvenna j. ,bethony j.m.
|
|
منبع
|
plos neglected tropical diseases - 2013 - دوره : 7 - شماره : 5
|
|
چکیده
|
Approximately 680 million people are at risk of infection with opisthorchis viverrini (ov) and clonorchis sinensis,with an estimated 10 million infected with ov in southeast asia alone. while opisthorchiasis is associated with hepatobiliary pathologies,such as advanced periductal fibrosis (apf) and cholangiocarcinoma (cca),animal models of ov infection show that immune-complex glomerulonephritis is an important renal pathology that develops simultaneously with hepatobiliary pathologies. a cardinal sign of immune-complex glomerulonephritis is the urinary excretion of immunoglobulin g (igg) (microproteinuria). in community-based studies in ov endemic areas along the chi river in northeastern thailand,we observed that over half of the participants had urine igg against a crude ov antigen extract (ov antigen). we also observed that elevated levels of urine igg to ov antigen were not associated with the intensity of ov infection,but were likely the result of immune-complex glomerulonephritis as seen in animal models of ov infection. moreover,we observed that urine igg to ov antigen was excreted at concentrations 21 times higher in individuals with apf and 158 times higher in individuals with cca than controls. we also observed that elevated urine igg to ov antigen could identify apf+ and cca+ individuals from non-cases. finally,individuals with urine igg to ov antigen had a greater risk of apf as determined by odds ratios (or = 6.69; 95%ci: 2.87,15.58) and a greater risk of cca (or = 71.13; 95%ci: 15.13,334.0) than individuals with no detectable level of urine igg to ov antigen. herein,we show for the first time the extensive burden of renal pathology in ov endemic areas and that a urine biomarker could serve to estimate risk for both renal and hepatobiliary pathologies during ov infection,i.e.,serve as a syndromic biomarker of the advanced pathologies from opisthorchiasis. © 2013 saichua et al.
|
|
|
|
|
آدرس
|
biomedical sciences program,graduate school,khon kaen university,khon kaen, Thailand, department of parasitology,faculty of medicine,khon kaen university,khon kaen,thailand,liver fluke and cholangiocarcinoma research center,faculty of medicine,khon kaen university,khon kaen, Thailand, department of microbiology,immunology and tropical medicine and center for the neglected diseases of poverty,george washington university,washington,dc, United States, department of microbiology,immunology and tropical medicine and center for the neglected diseases of poverty,george washington university,washington,dc, United States, department of clinical microscopy,faculty of associated medical sciences,khon kaen university,khon kaen, Thailand, department of pathology,faculty of medicine,khon kaen university,khon kaen, Thailand, department of parasitology,faculty of medicine,khon kaen university,khon kaen, Thailand, department of radiology,faculty of medicine,khon kaen university,khon kaen, Thailand, department of radiology,faculty of medicine,khon kaen university,khon kaen, Thailand, insituto rené rachou,laboratório de imunologia celular e molecular,belo horizonte, Brazil, department of surgery,faculty of medicine,khon kaen university,khon kaen, Thailand, infections and cancer,queensland institute of medical research,queensland, Australia, department of microbiology,immunology and tropical medicine and center for the neglected diseases of poverty,george washington university,washington,dc, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|