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Corticosteroids for Dengue - Why Don't They Work?
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نویسنده
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nguyen t.h.t. ,nguyen t.h.q. ,vu t.t. ,farrar j. ,hoang t.l. ,dong t.h.t. ,ngoc tran v. ,phung k.l. ,wolbers m. ,whitehead s.s. ,hibberd m.l. ,wills b. ,simmons c.p.
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منبع
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plos neglected tropical diseases - 2013 - دوره : 7 - شماره : 12
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چکیده
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Background:dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.findings:in vietnamese pediatric dengue cases randomized to early prednisolone therapy,81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. prominent among the 81 transcripts were those associated with t and nk cell cytolytic functions. additionally,prednisolone therapy was not associated with changes in plasma cytokine levels.conclusion:the inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.
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آدرس
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oxford university clinical research unit,hospital for tropical diseases,ho chi minh city, Viet Nam, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city, Viet Nam, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city, Viet Nam, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city,viet nam,centre for tropical medicine,nuffield department of medicine,university of oxford,oxford, United Kingdom, genome institute of singapore, Singapore, hospital for tropical diseases,ho chi minh city, Viet Nam, hospital for tropical diseases,ho chi minh city, Viet Nam, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city, Viet Nam, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city,viet nam,centre for tropical medicine,nuffield department of medicine,university of oxford,oxford, United Kingdom, laboratory of infectious diseases (lid),national institutes of allergy and infectious diseases,bethesda,md, United States, genome institute of singapore, Singapore, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city,viet nam,centre for tropical medicine,nuffield department of medicine,university of oxford,oxford, United Kingdom, oxford university clinical research unit,hospital for tropical diseases,ho chi minh city,viet nam,centre for tropical medicine,nuffield department of medicine,university of oxford,oxford,united kingdom,nossal institute of global health,school of population and global health,university of melbourne,parkville,vic, Australia
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Authors
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