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Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic,Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation
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نویسنده
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thivierge k. ,cotton s. ,schaefer d.a. ,riggs m.w. ,to j. ,lund m.e. ,robinson m.w. ,dalton j.p. ,donnelly s.m.
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منبع
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plos neglected tropical diseases - 2013 - دوره : 7 - شماره : 7
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چکیده
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Host defence peptides (hdps) are expressed throughout the animal and plant kingdoms. they have multifunctional roles in the defence against infectious agents of mammals,possessing both bactericidal and immune-modulatory activities. we have identified a novel family of molecules secreted by helminth parasites (helminth defence molecules; hdms) that exhibit similar structural and biochemical characteristics to the hdps. here,we have analyzed the functional activities of four hdms derived from schistosoma mansoni and fasciola hepatica and compared them to human,mouse,bovine and sheep hdps. unlike the mammalian hdps the helminth-derived hdms show no antimicrobial activity and are non-cytotoxic to mammalian cells (macrophages and red blood cells). however,both the mammalian- and helminth-derived peptides suppress the activation of macrophages by microbial stimuli and alter the response of b cells to cytokine stimulation. therefore,we hypothesise that hdms represent a novel family of hdps that evolved to regulate the immune responses of their mammalian hosts by retaining potent immune modulatory properties without causing deleterious cytotoxic effects. © 2013 thivierge et al.
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آدرس
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institute of parasitology,mcgill university,sainte-anne-de-bellevue,qc,canada,laboratoire de santé publique du québec,institut national de santé publique du québec,sainte-anne-de-bellevue,qc, Canada, institute of parasitology,mcgill university,sainte-anne-de-bellevue,qc, Canada, department of veterinary science and microbiology,university of arizona,tucson,az, United States, department of veterinary science and microbiology,university of arizona,tucson,az, United States, the ithree institute,university of technology sydney (uts),sydney, Australia, the ithree institute,university of technology sydney (uts),sydney, Australia, the ithree institute,university of technology sydney (uts),sydney,australia,school of biological sciences,queen's university belfast,medical biology centre,belfast, United Kingdom, institute of parasitology,mcgill university,sainte-anne-de-bellevue,qc, Canada, the ithree institute,university of technology sydney (uts),sydney, Australia
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Authors
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