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Assessment of Transmission in Trachoma Programs over Time Suggests No Short-Term Loss of Immunity
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نویسنده
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liu f. ,porco t.c. ,ray k.j. ,bailey r.l. ,mkocha h. ,muñoz b. ,quinn t.c. ,lietman t.m. ,west s.k.
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منبع
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plos neglected tropical diseases - 2013 - دوره : 7 - شماره : 7
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چکیده
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Trachoma programs have dramatically reduced the prevalence of the ocular chlamydia that cause the disease. some have hypothesized that immunity to the infection may be reduced because of program success in reducing the incidence of infection,and transmission may then increase. longitudinal studies of multiple communities would be necessary to test this hypothesis. here,we quantify transmission using an estimated basic reproduction number based on 32 communities during the first,second,and third years of an antibiotic treatment program. we found that there is little to no increase in the basic reproduction number over time. the estimated linear trend in the basic reproduction number,r̂0,was found to be -0.025 per year,95% ci -0.167 to 0.117 per year. we are unable to find evidence supporting any loss of immunity over the course of a 3-year program. this is encouraging,as it allows the possibility that repeated mass antibiotic distributions may eliminate infection from even the most severely affected areas.
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آدرس
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f.i. proctor foundation,university of california,san francisco,ca, United States, f.i. proctor foundation,university of california,san francisco,ca,united states,department of ophthalmology,university of california,san francisco,ca,united states,department of epidemiology and biostatistics,university of california,san francisco,ca, United States, f.i. proctor foundation,university of california,san francisco,ca, United States, faculty of infectious and tropical diseases,clinical research department,london school of hygiene and tropical medicine,london, United Kingdom, kongwa trachoma project,kongwa, Tanzania, wilmer eye institute,johns hopkins hospital,baltimore,md, United States, johns hopkins center for global health,johns hopkins university,baltimore,md, United States, f.i. proctor foundation,university of california,san francisco,ca,united states,department of ophthalmology,university of california,san francisco,ca,united states,department of epidemiology and biostatistics,university of california,san francisco,ca, United States, wilmer eye institute,johns hopkins hospital,baltimore,md, United States
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Authors
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