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Diversity and Epidemiology of Mokola Virus
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نویسنده
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kgaladi j. ,wright n. ,coertse j. ,markotter w. ,marston d. ,fooks a.r. ,freuling c.m. ,müller t.f. ,sabeta c.t. ,nel l.h.
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منبع
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plos neglected tropical diseases - 2013 - دوره : 7 - شماره : 10
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چکیده
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Mokola virus (mokv) appears to be exclusive to africa. although the first isolates were from nigeria and other congo basin countries,all reports over the past 20 years have been from southern africa. previous phylogenetic studies analyzed few isolates or used partial gene sequence for analysis since limited sequence information is available for mokv and the isolates were distributed among various laboratories. the complete nucleoprotein,phosphoprotein,matrix and glycoprotein genes of 18 mokv isolates in various laboratories were sequenced either using partial or full genome sequencing using pyrosequencing and a phylogenetic analysis was undertaken. the results indicated that mokv isolates from the republic of south africa,zimbabwe,central african republic and nigeria clustered according to geographic origin irrespective of the genes used for phylogenetic analysis,similar to that observed with lagos bat virus. a bayesian markov-chain-monte-carlo- (mcmc) analysis revealed the age of the most recent common ancestor (mrca) of mokv to be between 279 and 2034 years depending on the genes used. generally,all mokv isolates showed a similar pattern at the amino acid sites considered influential for viral properties. © 2013 kgaladi et al.
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آدرس
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department of microbiology and plant pathology,university of pretoria,pretoria, South Africa, department of microbiology and plant pathology,university of pretoria,pretoria, South Africa, department of microbiology and plant pathology,university of pretoria,pretoria, South Africa, department of microbiology and plant pathology,university of pretoria,pretoria, South Africa, wildlife zoonoses and vector-borne diseases research group,oie rabies ref. lab./who collaborating ctr. for the characters. of rabies and rabies-related viruses,department of virology,animal health veterinary laboratories agency (weybridge),addlestone,surrey, United Kingdom, wildlife zoonoses and vector-borne diseases research group,oie rabies ref. lab./who collaborating ctr. for the characters. of rabies and rabies-related viruses,department of virology,animal health veterinary laboratories agency (weybridge),addlestone,surrey,united kingdom,university of liverpool,department of clinical infection,microbiology and immunology,liverpool, United Kingdom, oie rabies reference laboratory/who collaborating centre for rabies surveillance and research,friedrich-loeffler-institut,federal research institute for animal health,institute of molecular biology,greifswald-insel riems, Germany, oie rabies reference laboratory/who collaborating centre for rabies surveillance and research,friedrich-loeffler-institut,federal research institute for animal health,institute of molecular biology,greifswald-insel riems, Germany, oie rabies reference laboratory,agricultural research council,onderstepoort veterinary institute,pretoria, South Africa, department of microbiology and plant pathology,university of pretoria,pretoria, South Africa
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Authors
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