|
|
|
|
Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3α and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children
|
|
|
|
|
|
|
|
نویسنده
|
stanisic d.i. ,javati s. ,kiniboro b. ,lin e. ,jiang j. ,singh b. ,meyer e.v.s. ,siba p. ,koepfli c. ,felger i. ,galinski m.r. ,mueller i.
|
|
منبع
|
plos neglected tropical diseases - 2013 - دوره : 7 - شماره : 11
|
|
چکیده
|
Background:plasmodium vivax is the most geographically widespread human malaria parasite. cohort studies in papua new guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas. although numerous p. vivax merozoite antigens are targets of naturally acquired antibodies,the role of many of these antibodies in protective immunity is yet unknown.methodology/principal findings:in a cohort of children aged 1-3 years,antibodies to different regions of merozoite surface protein 3α (pvmsp3α) and merozoite surface protein 9 (pvmsp9) were measured and related to prospective risk of p. vivax malaria during 16 months of active follow-up. overall,there was a low prevalence of antibodies to pvmsp3α and pvmsp9 proteins (9-65%). antibodies to the pvmsp3α n-terminal,block i and block ii regions increased significantly with age while antibodies to the pvmsp3α block i and pvmsp9 n-terminal regions were positively associated with concurrent p. vivax infection. independent of exposure (defined as the number of genetically distinct blood-stage infection acquired over time (molfob)) and age,antibodies specific to both pvmsp3α block ii (adjusted incidence ratio (airr) = 0.59,p = 0.011) and pvmsp9 n-terminus (airr = 0.68,p = 0.035) were associated with protection against clinical p. vivax malaria. this protection was most pronounced against high-density infections. for pvmsp3α block ii,the effect was stronger with higher levels of antibodies.conclusions:these results indicate that pvmsp3α block ii and pvmsp9 n-terminus should be further investigated for their potential as p. vivax vaccine antigens. controlling for molfob assures that the observed associations are not confounded by individual differences in exposure. © 2013 stanisic et al.
|
|
|
|
|
آدرس
|
walter and eliza hall institute,parkville,australia,papua new guinea institute of medical research,madang, Papua New Guinea, papua new guinea institute of medical research,madang, Papua New Guinea, papua new guinea institute of medical research,madang, Papua New Guinea, papua new guinea institute of medical research,madang, Papua New Guinea, emory vaccine center,yerkes national primate research centre,emory university,atlanta,ga, United States, emory vaccine center,yerkes national primate research centre,emory university,atlanta,ga, United States, emory vaccine center,yerkes national primate research centre,emory university,atlanta,ga, United States, papua new guinea institute of medical research,madang, Papua New Guinea, walter and eliza hall institute,parkville,australia,swiss tropical institute and public health institute,basel,switzerland,university of basel,basel, Switzerland, swiss tropical institute and public health institute,basel,switzerland,university of basel,basel, Switzerland, emory vaccine center,yerkes national primate research centre,emory university,atlanta,ga,united states,department of medicine,division of infectious disease,emory university,atlanta,ga, United States, walter and eliza hall institute,parkville,australia,papua new guinea institute of medical research,madang,papua new guinea,barcelona centre for international health res. (cresib,hospital clinic-universitat de barcelona),barcelona, Spain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|