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An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast
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نویسنده
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handee w. ,li x. ,hall k.w. ,deng x. ,li p. ,benning c. ,williams b.l. ,kuo m.-h.
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منبع
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plos genetics - 2016 - دوره : 12 - شماره : 2
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چکیده
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Intracellular triacylglycerol (tag) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. comparatively,little is known about tag’s role in other cellular functions. here we show a pro-longevity function of tag in the budding yeast saccharomyces cerevisiae. in yeast strains derived from natural and laboratory environments a correlation between high levels of tag and longer chronological lifespan was observed. increased tag abundance through the deletion of tag lipases prolonged chronological lifespan of laboratory strains,while diminishing tag biosynthesis shortened lifespan without apparently affecting vegetative growth. tag-mediated lifespan extension was independent of several other known stress response factors involved in chronological aging. because both lifespan regulation and tag metabolism are conserved,this cellular pro-longevity function of tag may extend to other organisms. © 2016 handee et al.
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آدرس
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department of cell and molecular biology,michigan state university,east lansing,mi, United States, doe-plant research laboratory,michigan state university,east lansing,mi,united states,department of plant biology,michigan state university,east lansing,mi,united states,department of plant biology,carnegie institution for science,stanford,ca, United States, department of integrative biology,michigan state university,east lansing,mi, United States, department of biochemistry and molecular biology,michigan state university,east lansing,mi, United States, department of biochemistry and molecular biology,michigan state university,east lansing,mi, United States, department of biochemistry and molecular biology,michigan state university,east lansing,mi, United States, department of integrative biology,michigan state university,east lansing,mi, United States, department of biochemistry and molecular biology,michigan state university,east lansing,mi, United States
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Authors
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