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The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions
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نویسنده
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guan l. ,ma x. ,zhang j. ,liu j.-j. ,wang y. ,ding m.
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منبع
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plos genetics - 2016 - دوره : 12 - شماره : 7
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چکیده
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Eukaryotic cells extend a variety of surface protrusions to direct cell motility. formation of protrusions is mediated by coordinated actions between the plasma membrane and the underlying actin cytoskeleton. here,we found that the single calponin homology (ch) domain-containing protein chdp-1 induces the formation of cell protrusions in c. elegans. chdp-1 is anchored to the cortex through its amphipathic helix. chdp-1 associates through its ch domain with the small gtpase rac1/ced-10,which is a key regulator of the actin cytoskeleton. chdp-1 preferentially binds to the gtp-bound active form of the ced-10 protein and preserves the membrane localization of gtp-ced-10. hence,by coupling membrane expansion to rac1-mediated actin dynamics,chdp-1 promotes the formation of cellular protrusions in vivo. © 2016 guan et al.
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آدرس
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state key laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,beijing, China, state key laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,beijing,china,university of chinese academy of sciences,beijing, China, state key laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,beijing,china,university of chinese academy of sciences,beijing, China, state key laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,beijing,china,cas center for excellence in brain science and intelligence technology,shanghai, China, state key laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,beijing, China, state key laboratory of molecular developmental biology,institute of genetics and developmental biology,chinese academy of sciences,beijing,china,cas center for excellence in brain science and intelligence technology,shanghai, China
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Authors
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