|
|
|
|
Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers
|
|
|
|
|
|
|
|
نویسنده
|
yoo s.-k. ,lee s. ,kim s.-j. ,jee h.-g. ,kim b.-a. ,cho h. ,song y.s. ,cho s.w. ,won j.-k. ,shin j.-y. ,park d.j. ,kim j.-i. ,lee k.e. ,park y.j. ,seo j.-s.
|
|
منبع
|
plos genetics - 2016 - دوره : 12 - شماره : 8
|
|
چکیده
|
Follicular thyroid carcinoma (ftc) and benign follicular adenoma (fa) are indistinguishable by preoperative diagnosis due to their similar histological features. here we report the first rna sequencing study of these tumors,with data for 30 minimally invasive ftcs (miftcs) and 25 fas. we also compared 77 classical papillary thyroid carcinomas (cptcs) and 48 follicular variant of ptcs (fvptcs) to observe the differences in their molecular properties. mutations in h/k/nras,dicer1,eif1ax,idh1,pten,sos1,and spop were identified in miftc or fa. we identified a low frequency of fusion genes in miftc (only one,pax8–pparg),but a high frequency of that in ptc (17.60%). the frequencies of brafv600e and h/k/nras mutations were substantially different in miftc and cptc,and those of fvptc were intermediate between miftc and cptc. gene expression analysis demonstrated three molecular subtypes regardless of their histological features,including non–braf–non–ras (nbnr),as well as braf–like and ras–like. the novel molecular subtype,nbnr,was associated with dicer1,eif1ax,idh1,pten,sos1,spop,and pax8–pparg. the transcriptome of miftc or encapsulated fvptc was indistinguishable from that of fa,providing a molecular explanation for the similarly indolent behavior of these tumors. we identified upregulation of genes that are related to mitochondrial biogenesis including esrra and ppargc1a in oncocytic follicular thyroid neoplasm. arm-level copy number variations were correlated to histological and molecular characteristics. these results expanded the current molecular understanding of thyroid cancer and may lead to new diagnostic and therapeutic approaches to the disease. © 2016 yoo et al.
|
|
|
|
|
آدرس
|
genomic medicine institute,medical research center,seoul national university,seoul,south korea,interdisciplinary program in bioinformatics,seoul national university,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul, South Korea, department of surgery,seoul national university college of medicine,seoul,south korea,cancer research institute,seoul national university college of medicine,seoul, South Korea, research institute,national medical center,seoul, South Korea, cancer research institute,seoul national university college of medicine,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul,south korea,department of biomedical sciences,seoul national university graduate school,seoul, South Korea, department of internal medicine,seoul national university college of medicine,seoul, South Korea, department of internal medicine,seoul national university college of medicine,seoul, South Korea, department of pathology,seoul national university college of medicine,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul,south korea,macrogen inc.,seoul, South Korea, department of internal medicine,seoul national university college of medicine,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul,south korea,department of biomedical sciences,seoul national university graduate school,seoul,south korea,department of biochemistry and molecular biology,seoul national university college of medicine,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul,south korea,department of surgery,seoul national university college of medicine,seoul,south korea,cancer research institute,seoul national university college of medicine,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul,south korea,department of internal medicine,seoul national university college of medicine,seoul, South Korea, genomic medicine institute,medical research center,seoul national university,seoul,south korea,interdisciplinary program in bioinformatics,seoul national university,seoul,south korea,department of biomedical sciences,seoul national university graduate school,seoul,south korea,macrogen inc.,seoul,south korea,department of biochemistry and molecular biology,seoul national university college of medicine,seoul, South Korea
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|