plos genetics سال:2016 - دوره:12

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plos genetics
سال:2016 - دوره:12 - شماره:12

A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans A Hox-Embedded Long Noncoding RNA: Is It All Hot Air? A Kinase-Phosphatase Switch Transduces Environmental Information into a Bacterial Cell Cycle Circuit A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies Allelic Variation in CXCL16 Determines CD3+T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion Alternative Splicing within and between Drosophila Species,Sexes,Tissues,and Developmental Stages Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment Bringing PLOS Genetics Editors to Preprint Servers Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1 Cell Cycle Constraints and Environmental Control of Local DNA Hypomethylation in α-Proteobacteria Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1,Mck1 and Rim15 Kinases Comment on Hotair Is Dispensable for Mouse Development Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis Craniofacial Ciliopathies and the Interpretation of Hedgehog Signal Transduction DNA Methylation Signatures of the Plant Chromomethyltransferases Deep Reads: Favorites from a Few Different Shelves Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome Epistasis and Entropy Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis Gene Expression Differences in Prostate Cancers between Young and Old Men Hotair Is Dispensible for Mouse Development Identification of a Novel L-rhamnose Uptake Transporter in the Filamentous Fungus Aspergillus niger Interaction of Prions Causes Heritable Traits in Saccharomyces cerevisiae Intracellular Zn(II) Intoxication Leads to Dysregulation of the PerR Regulon Resulting in Heme Toxicity in Bacillus subtilis Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen,Cryptococcus neoformans Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome Middle Age Has Its Advantages Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration Mutation Rate Variation is a Primary Determinant of the Distribution of Allele Frequencies in Humans Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception NUCLEAR FACTOR Y,Subunit A (NF-YA) Proteins Positively Regulate Flowering and Act Through FLOWERING LOCUS T Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling On the Spatial Organization of mRNA,Plasmids,and Ribosomes in a Bacterial Host Overexpressing Membrane Proteins PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements Shared Information between Residues Is Sufficient to Detect Pairwise Epistasis in a Protein Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK–JNK Signaling Pathway in Axon Regeneration The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6 The Jujube Genome Provides Insights into Genome Evolution and the Domestication of Sweetness/Acidity Taste in Fruit Trees The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets Transcriptional Orchestration of the Global Cellular Response of a Model Pennate Diatom to Diel Light Cycling under Iron Limitation Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response Unique Function of the Bacterial Chromosome Segregation Machinery in Apically Growing Streptomyces - Targeting the Chromosome to New Hyphal Tubes and its Anchorage at the Tips Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data