plos genetics سال:2017 - دوره:13

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plos genetics
سال:2017 - دوره:13 - شماره:5

A fungal transcription factor essential for starch degradation affects integration of carbon and nitrogen metabolism A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA Amino acid metabolites that regulate G protein signaling during osmotic stress Amplifying recombination genome-wide and reshaping crossover landscapes in Brassicas An R2R3-type MYB transcription factor,GmMYB29,regulates isoflavone biosynthesis in soybean Arabidopsis RAD51,RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma Conserved properties of Drosophila insomniac link sleep regulation and synaptic function Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice Evolutionary forces affecting synonymous variations in plant genomes Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness Global analysis of double-strand break processing reveals in vivo properties of the helicase-nuclease complex AddAB Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless Human mutations in integrator complex subunits link transcriptome integrity to brain development Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump Identifying pathogenicity of human variants via paralog-based yeast complementation Identifying systematic heterogeneity patterns in genetic association meta-analysis studies Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis Lack of the PGA exopolysaccharide in Salmonella as an adaptive trait for survival in the host Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains Long-range control of gene expression via RNA-directed DNA methylation MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain MicroRNA319-regulated TCPs interact with FBHs and PFT1 to activate CO transcription and control flowering time in Arabidopsis MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains Multifunctional glial support by Semper cells in the Drosophila retina Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast Pheromone independent unisexual development in Cryptococcus neoformans Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans Polymorphisms in the yeast galactose sensor underlie a natural continuum of nutrient-decision phenotypes Power provides protection: Genetic robustness in yeast depends on the capacity to generate energy Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability,depending on the nature of the DNA lesion Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicity TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan The fog of war: How network buffering protects plants’ defense secrets from pathogens The highly buffered Arabidopsis immune signaling network conceals the functions of its components Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase Two extended haplotype blocks are associated with adaptation to high altitude habitats in East African honey bees USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis