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MiR-125a Is a critical modulator for neutrophil development
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نویسنده
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qin y. ,wu l. ,ouyang y. ,zhou p. ,zhou h. ,wang y. ,ma j. ,zhang j. ,chen y. ,qian j. ,tang y. ,shen n.
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منبع
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plos genetics - 2017 - دوره : 13 - شماره : 10
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چکیده
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Micrornas are universal post-transcriptional regulators in genomes. they have the ability of buffering gene expressional programs,contributing to robustness of biological systems and playing important roles in development,physiology and diseases. here,we identified a microrna,mir-125a,as a positive regulator of granulopoiesis. mir125a knockout mice show reduced infiltration of neutrophils in the lung and alleviated tissue destruction after endotoxin challenge as a consequence of decreased neutrophil numbers. furthermore,we demonstrated that this significant reduction of neutrophils was due to impaired development of granulocyte precursors to mature neutrophils in an intrinsic manner. we showed that socs3,a critical repressor for granulopoiesis,was a target of mir-125a. overall,our study revealed a new microrna regulating granulocyte development and supported a model in which mir-125a acted as a fine-tuner of granulopoiesis. © 2017 qin et al.
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آدرس
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department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences and shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences and shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China, department of rheumatology and shanghai institute of rheumatology,renji hospital,shanghai jiao tong university school of medicine,shanghai,china,institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences and shanghai jiao tong university school of medicine,shanghai,china,state key laboratory of oncogenes and related genes,shanghai cancer institute,renji hospital,shanghai,china,collaborative innovation center for translational medicine,shanghai jiao tong university school of medicine,shanghai,china,the center for autoimmune genomics and etiology (cage),cincinnati children's hospital medical center,cincinnati,oh,united states,china–australia centre for personalised immunology,renji hospital,shanghai jiao tong university school of medicine,shanghai, China
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Authors
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