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Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae
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نویسنده
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dahal b.k. ,kadyrova l.y. ,delfino k.r. ,rogozin i.b. ,gujar v. ,lobachev k.s. ,kadyrov f.a.
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منبع
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plos genetics - 2017 - دوره : 13 - شماره : 10
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چکیده
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Heterochromatin contains a significant part of nuclear dna. little is known about the mechanisms that govern heterochromatic dna stability. we show here that in the yeast saccharomyces cerevisiae (i) dna mismatch repair (mmr) is required for the maintenance of heterochromatic dna stability,(ii) mutlα (mlh1-pms1 heterodimer),mutsα (msh2-msh6 heterodimer),mutsβ (msh2-msh3 heterodimer),and exo1 are involved in mmr at heterochromatin,(iii) exo1-independent mmr at heterochromatin frequently leads to the formation of pol ζ-dependent mutations,(iv) mmr cooperates with the proofreading activity of pol ε and the histone acetyltransferase rtt109 in the maintenance of heterochromatic dna stability,(v) repair of base-base mismatches at heterochromatin is less efficient than repair of base-base mismatches at euchromatin,and (vi) the efficiency of repair of 1-nt insertion/deletion loops at heterochromatin is similar to the efficiency of repair of 1-nt insertion/deletion loops at euchromatin. © 2017 public library of science. all rights reserved.
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آدرس
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department of biochemistry and molecular biology,southern illinois university school of medicine,carbondale,il, United States, department of biochemistry and molecular biology,southern illinois university school of medicine,carbondale,il, United States, center for clinical research,southern illinois university school of medicine,springfield,il, United States, national center for biotechnology information,national library of medicine,national institutes of health,bethesda,md, United States, department of biochemistry and molecular biology,southern illinois university school of medicine,carbondale,il, United States, school of biological sciences and institute for bioengineering and bioscience,georgia institute of technology,atlanta,ga, United States, department of biochemistry and molecular biology,southern illinois university school of medicine,carbondale,il, United States
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Authors
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