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Global Genetic Variations Predict Brain Response to Faces
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نویسنده
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dickie e.w. ,tahmasebi a. ,french l. ,kovacevic n. ,banaschewski t. ,barker g.j. ,bokde a. ,büchel c. ,conrod p. ,flor h. ,garavan h. ,gallinat j. ,gowland p. ,heinz a. ,ittermann b. ,lawrence c. ,mann k. ,martinot j.-l. ,nees f. ,nichols t. ,lathrop m. ,loth e. ,pausova z. ,rietschel m. ,smolka m.n. ,ströhle a. ,toro r. ,schumann g. ,schumann g. ,paus t. ,reed l. ,williams s. ,loth e. ,lourdusamy a. ,costafreda s. ,cattrell a. ,nymberg c. ,topper l. ,smith l. ,havatzias s. ,stueber k. ,mallik c. ,clarke t.-k. ,stacey d. ,peng wong c. ,werts h. ,andrew c. ,desrivieres s. ,carvalho f. ,heinz a. ,gallinat j. ,häke i. ,ivanov n. ,klär a. ,reuter j. ,palafox c. ,hohmann c. ,schilling c. ,lüdemann k. ,romanowski a. ,ströhle a. ,wolff e. ,rapp m. ,ittermann b. ,brü hl r. ,ihlenfeld a. ,walaszek b. ,schubert f. ,garavan h. ,connolly c. ,jones j. ,lalor e. ,mccabe e. ,níshiothcháin a. ,whelan r. ,spanagel r. ,leonardi-essmann f. ,sommer w. ,flor h. ,nees f. ,struve m. ,banaschewski t. ,poustka l. ,steiner s. ,mann k. ,buehler m. ,vollstaedt-klein s. ,rietschel m. ,stolzenburg e. ,schmal c. ,paus t. ,heym n. ,lawrence c. ,newman c. ,pausova z. ,smolka m. ,huebner t. ,ripke s. ,mennigen e. ,muller k. ,ziesch v. ,büchel c. ,bromberg u. ,fadai t. ,lueken l. ,yacubian j. ,finsterbusch j. ,martinot j.-l. ,artiges e. ,gollier briand f. ,massicotte j. ,bordas n. ,miranda r. ,bricaud z. ,paillère martinot m.l. ,pionne-dax n. ,zilbovicius m. ,boddaert n. ,cachia a. ,mangin j.-f. ,poline j.-b. ,barbot a. ,schwartz y. ,lalanne c. ,frouin v. ,thyreau b. ,dalley j. ,mar a. ,robbins t. ,subramaniam n. ,theobald d. ,richmond n. ,de rover m. ,molander a. ,jordan e.
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منبع
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plos genetics - 2014 - دوره : 10 - شماره : 8
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چکیده
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Face expressions are a rich source of social signals. here we estimated the proportion of phenotypic variance in the brain response to facial expressions explained by common genetic variance captured by ∼500,000 single nucleotide polymorphisms. using genomic-relationship-matrix restricted maximum likelihood (greml),we related this global genetic variance to that in the brain response to facial expressions,as assessed with functional magnetic resonance imaging (fmri) in a community-based sample of adolescents (n = 1,620). brain response to facial expressions was measured in 25 regions constituting a face network,as defined previously. in 9 out of these 25 regions,common genetic variance explained a significant proportion of phenotypic variance (40–50%) in their response to ambiguous facial expressions; this was not the case for angry facial expressions. across the network,the strength of the genotype-phenotype relationship varied as a function of the inter-individual variability in the number of functional connections possessed by a given region (r2 = 0.38,p<0.001). furthermore,this variability showed an inverted u relationship with both the number of observed connections (r2 = 0.48,p<0.001) and the magnitude of brain response (r2 = 0.32,p<0.001). thus,a significant proportion of the brain response to facial expressions is predicted by common genetic variance in a subset of regions constituting the face network. these regions show the highest inter-individual variability in the number of connections with other network nodes,suggesting that the genetic model captures variations across the adolescent brains in co-opting these regions into the face network. © 2014 dickie et al.
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آدرس
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rotman research institute,university of toronto,toronto,on, Canada, rotman research institute,university of toronto,toronto,on,canada,philips research north america,briarcliff manor,new york, United States, rotman research institute,university of toronto,toronto,on, Canada, rotman research institute,university of toronto,toronto,on, Canada, central institute of mental health,mannheim,germany,university of heidelberg,heidelberg, Germany, institute of psychiatry,king’s college london,london,united kingdom,institute of psychiatry,king’s college,london, United Kingdom, institute of neuroscience,trinity college dublin,dublin, Ireland, universitaetsklinikum hamburg eppendorf,hamburg, Germany, institute of psychiatry,king’s college london,london,united kingdom,department of psychiatry,universite de montreal,chu ste justine hospital,montreal,qc, Canada, central institute of mental health,mannheim,germany,university of heidelberg,heidelberg, Germany, institute of neuroscience,trinity college dublin,dublin,ireland,departments of psychiatry and psychology,university of vermont,burlington,vt, United States, department of psychiatry and psychotherapy,charité – universitätsmedizin berlin,berlin, Germany, sir peter mansfield mr centre,university of nottingham,nottingham,united kingdom,schools of psychology,physics and biomedical sciences,university of nottingham, United Kingdom, department of psychiatry and psychotherapy,charité – universitätsmedizin berlin,berlin, Germany, physikalisch-technische bundesanstalt (ptb),braunschweig und berlin,berlin, Germany, school of psychology,university of nottingham,nottingham, United Kingdom, central institute of mental health,mannheim,germany,university of heidelberg,heidelberg, Germany, institut national de la santé et de la recherche médicale,inserm cea unit 1000 “imaging & psychiatry”,university paris sud,orsay,france,ap-hp department of adolescent psychopathology and medicine,maison de solenn,university paris descartes,paris, France, central institute of mental health,mannheim,germany,university of heidelberg,heidelberg, Germany, university of warwick,coventry, United Kingdom, centre national de génotypage,evry, France, institute of psychiatry,king’s college london,london,united kingdom,mrc social,genetic and developmental psychiatry (sgdp) centre,london, United Kingdom, the hospital for sick children,university of toronto,toronto,on, Canada, central institute of mental health,mannheim,germany,university of heidelberg,heidelberg, Germany, department of psychiatry and psychotherapy,technische universität dresden,dresden,germany,neuroimaging center,department of psychology,technische universität dresden,dresden, Germany, department of psychiatry and psychotherapy,charité – universitätsmedizin berlin,berlin, Germany, institute pasteur,paris, France, institute of psychiatry,king’s college london,london,united kingdom,mrc social,genetic and developmental psychiatry (sgdp) centre,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, rotman research institute,university of toronto,toronto,on,canada,school of psychology,university of nottingham,nottingham,united kingdom,institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, institute of psychiatry,king’s college,london, United Kingdom, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, department of psychiatry and psychotherapy,campus charité mitte,charité - universitätsmedizin,berlin, Germany, physikalisch-technische bundesanstalt,berlin, Germany, physikalisch-technische bundesanstalt,berlin, Germany, physikalisch-technische bundesanstalt,berlin, Germany, physikalisch-technische bundesanstalt,berlin, Germany, physikalisch-technische bundesanstalt,berlin, Germany, institute of neuroscience,trinity college,dublin, Ireland, institute of neuroscience,trinity college,dublin, Ireland, institute of neuroscience,trinity college,dublin, Ireland, institute of neuroscience,trinity college,dublin, Ireland, institute of neuroscience,trinity college,dublin, Ireland, institute of neuroscience,trinity college,dublin, Ireland, institute of neuroscience,trinity college,dublin, Ireland, department of psychopharmacology,central institute of mental health,mannheim, Germany, department of psychopharmacology,central institute of mental health,mannheim, Germany, department of psychopharmacology,central institute of mental health,mannheim, Germany, department of cognitive and clinical neuroscience,central institute of mental health,mannheim, Germany, department of cognitive and clinical neuroscience,central institute of mental health,mannheim, Germany, department of cognitive and clinical neuroscience,central institute of mental health,mannheim, Germany, department of child and adolescent psychiatry,central institute of mental health,mannheim, Germany, department of child and adolescent psychiatry,central institute of mental health,mannheim, Germany, department of child and adolescent psychiatry,central institute of mental health,mannheim, Germany, department of addictive behaviour and addiction medicine, Germany, department of addictive behaviour and addiction medicine, Germany, department of addictive behaviour and addiction medicine, Germany, department of genetic epidemiology in psychiatry,central institute of mental health,mannheim, Germany, department of genetic epidemiology in psychiatry,central institute of mental health,mannheim, Germany, department of genetic epidemiology in psychiatry,central institute of mental health,mannheim, Germany, schools of psychology,physics and biomedical sciences,university of nottingham, United Kingdom, schools of psychology,physics and biomedical sciences,university of nottingham, United Kingdom, schools of psychology,physics and biomedical sciences,university of nottingham, United Kingdom, schools of psychology,physics and biomedical sciences,university of nottingham, United Kingdom, schools of psychology,physics and biomedical sciences,university of nottingham, United Kingdom, technische universitaet dresden, Germany, technische universitaet dresden, Germany, technische universitaet dresden, Germany, technische universitaet dresden, Germany, technische universitaet dresden, Germany, technische universitaet dresden, Germany, department of systems neuroscience,university medical center hamburg-eppendorf,hamburg, Germany, department of systems neuroscience,university medical center hamburg-eppendorf,hamburg, Germany, department of systems neuroscience,university medical center hamburg-eppendorf,hamburg, Germany, department of systems neuroscience,university medical center hamburg-eppendorf,hamburg, Germany, department of systems neuroscience,university medical center hamburg-eppendorf,hamburg, Germany, department of systems neuroscience,university medical center hamburg-eppendorf,hamburg, Germany, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, institut national de la santé et de la recherche médicale,service hospitalier frédéric joliot,orsay, France, neurospin,commissariat à l’energie atomique,paris, France, neurospin,commissariat à l’energie atomique,paris, France, neurospin,commissariat à l’energie atomique,paris, France, neurospin,commissariat à l’energie atomique,paris, France, neurospin,commissariat à l’energie atomique,paris, France, neurospin,commissariat à l’energie atomique,paris, France, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom, behavioural and clinical neurosciences institute,department of experimental psychology,university of cambridge, United Kingdom
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Authors
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