|
|
|
|
EVA-1 Functions as an UNC-40 Co-receptor to Enhance Attraction to the MADD-4 Guidance Cue in Caenorhabditis elegans
|
|
|
|
|
|
|
|
نویسنده
|
chan k.k.m. ,seetharaman a. ,bagg r. ,selman g. ,zhang y. ,kim j. ,roy p.j.
|
|
منبع
|
plos genetics - 2014 - دوره : 10 - شماره : 8
|
|
چکیده
|
We recently discovered a secreted and diffusible midline cue called madd-4 (an adamtsl) that guides migrations along the dorsoventral axis of the nematode caenorhabditis elegans. we showed that the transmembrane receptor,unc-40 (dcc),whose canonical ligand is the unc-6 (netrin) guidance cue,is required for extension towards madd-4. here,we demonstrate that madd-4 interacts with an eva-1/unc-40 co-receptor complex to attract cell extensions. eva-1 is a conserved transmembrane protein with predicted galactose-binding lectin domains. eva-1 functions in the same pathway as madd-4,physically interacts with both madd-4 and unc-40,and enhances unc-40's sensitivity to the madd-4 cue. this enhancement is especially important in the presence of unc-6. in eva-1's absence,unc-6 interferes with unc-40's responsiveness to madd-4; in unc-6's absence,unc-40's responsiveness to madd-4 is less dependent on eva-1. by enabling unc-40 to respond to madd-4 in the presence of unc-6,eva-1 may increase the precision by which unc-40-directed processes can reach their madd-4-expressing targets within a field of the unc-6 guidance cue. © 2014 chan et al.
|
|
|
|
|
آدرس
|
department of molecular genetics,university of toronto,toronto,on,canada,the donnelly centre for cellular and biomolecular research,university of toronto,toronto,on, Canada, department of molecular genetics,university of toronto,toronto,on,canada,the donnelly centre for cellular and biomolecular research,university of toronto,toronto,on,canada,the collaborative programme in developmental biology,university of toronto,toronto,on, Canada, department of molecular genetics,university of toronto,toronto,on,canada,the donnelly centre for cellular and biomolecular research,university of toronto,toronto,on, Canada, department of molecular genetics,university of toronto,toronto,on,canada,the donnelly centre for cellular and biomolecular research,university of toronto,toronto,on, Canada, department of molecular genetics,university of toronto,toronto,on,canada,the donnelly centre for cellular and biomolecular research,university of toronto,toronto,on, Canada, department of molecular genetics,university of toronto,toronto,on, Canada, department of molecular genetics,university of toronto,toronto,on,canada,the donnelly centre for cellular and biomolecular research,university of toronto,toronto,on,canada,the collaborative programme in developmental biology,university of toronto,toronto,on, Canada
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|